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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Zhao, Chunyan Wang, Jianping Zhao, Yuanzheng Liu, Chunling Zhu, Zhongjun Jiang, Chao |
Description | Author Affiliation: Wang J ( The Fifth Affiliated Hospital of Zhengzhou University, Henan 450052, P.R. China.) |
Abstract | Recent studies have indicated that progesterone (PROG) reduces the expression of inflammatory factors in brain tissue. The present study was designed to investigate whether PROG inhibits the inflammatory response and the infiltration of inflammatory cells in the brain. One hundred and seventy-six adult male Sprague-Dawley rats were randomly divided into four groups: a sham-operated (control) group, a permanent middle cerebral artery occlusion (pMCAO) group, a vehicle-treated group and a PROG-treated group. After pMCAO, the rats received an initial intraperitoneal injection of PROG (8 mg/kg) or vehicle at 1 h post-occlusion, followed by subcutaneous injections at 6, 24 and 48 h. The expression levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and CD68 in the brain were measured by immunohistochemistry and Western blotting. The level of myeloperoxidase (MPO) activity was detected by spectrophotometry. The rats were sacrificed 72 h after surgery and isolated brain was sectioned into coronal slices and stained with 2,3,5-triphenyltetrazolium chloride (TTC). Western blotting and spectrophotometry revealed that the expression levels of ICAM-1, VCAM-1, CD68 and MPO were reduced in the brain tissue of PROG-treated rats. In addition, PROG-treated rats showed a substantial reduction in the infarct volume compared to vehicle controls. PROG effectively inhibited the inflammatory response and reduced the infiltration of leukocytes in the ischemic brain by inhibiting the expression of ICAM-1 and VCAM-1. |
ISSN | 17912997 |
e-ISSN | 17913004 |
Journal | Molecular Medicine Reports |
Issue Number | 2 |
Volume Number | 4 |
Language | English |
Publisher | Spandidos Publications |
Publisher Date | 2011-03-01 |
Publisher Place | Greece |
Access Restriction | Open |
Subject Keyword | Infarction, Middle Cerebral Artery Complications Drug Therapy Inflammation Progesterone Therapeutic Use Animals Antigens, Cd Metabolism Antigens, Differentiation, Myelomonocytic Blotting, Western Brain Drug Effects Enzymology Pathology Brain Infarction Intercellular Adhesion Molecule-1 Peroxidase Pharmacology Rats, Sprague-dawley Vascular Cell Adhesion Molecule-1 Discipline Molecular Biology |
Content Type | Text |
Resource Type | Article |
Subject | Genetics Molecular Biology Molecular Medicine Cancer Research Biochemistry Oncology |
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