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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Johnson, R. G. Blum, H. Nioka, S. |
Description | Author Affiliation: Blum H ( Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.); |
Abstract | The in vivo activation and turnover rates of the sodium pump (Na+, K(+)-ATPase) were investigated in the electrocytes of the electric organ of the elasmobranch Narcine brasiliensis. The Narcine electric organ appears to be an excellent model for the study of sodium pump activation in an excitable tissue. The sodium transmembrane gradient and high-energy phosphagens were concurrently measured by 23Na and 31P NMR spectroscopy. The resting electric organ, which depends primarily on anaerobic metabolism, displays a high concentration of phosphocreatine (PCr). It has an intracellular sodium concentration ([Na+]i) of 20 +/- 10 milliequivalents/liter as estimated by NMR. Electrical stimulation of the nerves innervating the electric organ results in an increase in [Na+]i in the electrolyte and rapid depletion of PCr. Ouabain causes an 85% decrease in utilization of high-energy phosphagens, indicating that rapid PCr turnover in this tissue is mainly due to Na+, K(+)-ATPase activity. From these data we can determine that the rate of sodium pump turnover increases by greater than 3 orders of magnitude within several hundred milliseconds. In excised unstimulated electric organ slices, changes in [Na+]i equivalent to those occurring with stimulation, but induced by hyperosmolar conditions, do not result in increased PCr hydrolysis. We conclude that cholinergic stimulation of the electric organ causes a rapid and extremely large increase in sodium pump turnover, which is regulated predominantly by factors other than [Na+]i. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 3 |
Volume Number | 87 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 1990-03-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Electric Organ Enzymology Sodium-Potassium-Exchanging ATPase Metabolism Animals Cell Membrane Electric Stimulation Enzyme Activation Kinetics Magnetic Resonance Spectroscopy Ouabain Pharmacology Phosphocreatine Torpedo Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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