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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Rapp, U. R. Wang, H. G. Reed, J. C. Takayama, S. |
Description | Author Affiliation: Wang HG ( The Burnham Institute, La Jolla, CA 92037, USA.); |
Abstract | The Bcl-2 protein blocks programmed cell death (apoptosis) through an unknown mechanism. Previously we identified a Bcl-2 interacting protein BAG-1 that enhances the anti-apoptotic effects of Bcl-2. Like BAG-1, the serine/threonine protein kinase Raf-1 also can functionally cooperate with Bcl-2 in suppressing apoptosis. Here we show that Raf-1 and BAG-1 specifically interact in vitro and in yeast two-hybrid assays. Raf-1 and BAG-1 can also be coimmunoprecipitated from mammalian cells and from insect cells infected with recombinant baculoviruses encoding these proteins. Furthermore, bacterially-produced BAG-1 protein can increase the kinase activity of Raf-1 in vitro. BAG-1 also activates this mammalian kinase in yeast. These observations suggest that the Bcl-2 binding protein BAG-1 joins Ras and 14-3-3 proteins as potential activators of the kinase Raf-1. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 14 |
Volume Number | 93 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 1996-08-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Apoptosis Carrier Proteins Metabolism Proto-Oncogene Proteins Animals Cercopithecus Aethiops Cloning, Molecular DNA-Binding Proteins Enzyme Activation Glutathione Transferase Kinetics Mammals Protein-Serine-Threonine Kinases Protein-Tyrosine Kinases Proto-Oncogene Proteins C-bcl-2 Proto-Oncogene Proteins C-raf Recombinant Fusion Proteins Saccharomyces Cerevisiae Spodoptera Transcription Factors Transfection Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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