NDLI: Diffusion-weighted imaging in optic neuritis.

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Diffusion-weighted imaging in optic neuritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fatima, Zareen Motosugi, Utaroh Muhi, Ali Hori, Masaaki Ishigame, Keiichi Araki, Tsutomu
Description	Country affiliation: Japan Author Affiliation: Fatima Z ( Department of Radiology, University of Yamanashi, Yamanashi, Japan.)
Abstract	PURPOSE: To evaluate imaging characteristics of optic nerves by using magnetic resonance imaging, especially diffusion-weighted imaging (DWI) with apparent diffusion coefficient measurements in acute and chronic phases of optic neuritis (ON). MATERIALS AND METHODS: A retrospective study was conducted by using records of 14 patients with clinically suspected acute ON (15 nerves), 5 chronic ON (7 nerves), and 11 normal volunteers with no eye symptoms were used as controls. Magnetic resonance imaging was performed by a 1.5T scanner. Affected nerves were evaluated for sizes, signal characteristics on DWI and T2-weighted imaging (T2WI), contrast enhancement, and apparent diffusion coefficient values. Visually assessed characteristics were compared between the acute and chronic, whereas apparent diffusion coefficient values were assessed among acute ON, chronic ON, and the control groups by using the Fisher exact test and Mann-Whitney U test. RESULTS: There were significant differences in the diameter of the optic nerves, hyperintensity on DWI, and enhancement characteristics on post-enhanced images in acute and chronic phases of ON (P = .0001, P < .0001, and P = .0022, respectively), apparent diffusion coefficient values of the optic nerves in acute ON, chronic ON, and control groups also differed significantly from each other. CONCLUSION: In conclusion, DWI can add valuable information in assessment of damage to nerve and neuronal barriers and thus in predicting recovery in cases of ON.
File Format	HTM / HTML
ISSN	08465371
Issue Number	1
Volume Number	64
e-ISSN	14882361
Journal	Canadian Association of Radiologists Journal
Language	English
Publisher	Elsevier
Publisher Date	2013-02-01
Publisher Place	Canada
Access Restriction	Subscribed
Subject Keyword	Discipline Radiology Diffusion Magnetic Resonance Imaging Methods Optic Neuritis Diagnosis Adolescent Adult Aged Case-control Studies Child Contrast Media Female Gadolinium Dtpa Humans Male Middle Aged Retrospective Studies Statistics, Nonparametric Journal Article
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Eukaryota Nervous System Diseases Organic Chemicals Chemical Actions and Uses Diagnosis Investigative Techniques Persons
Subject	Radiology, Nuclear Medicine and Imaging

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