NDLI: The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh.

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The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh.

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The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mehrabi Bahar, Mostafa Jabbari Nooghabi, Azadeh Jabbari Nooghabi, Mehdi Jangjoo, Ali
Description	Country affiliation: Iran Author Affiliation: Mehrabi Bahar M ( Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Jabbari Nooghabi A ( Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.); Jabbari Nooghabi M ( Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran); Jangjoo A ( Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: jangjooa@mums.ac.ir.)
Abstract	OBJECTIVE: There are controversies about the benefits of prophylactic antibiotics in the prevention of postoperative surgical site infection (SSI) in mesh herniorrhaphy for a long time. This study aimed to evaluate the effectiveness and efficacy of systemic prophylactic cefazolin in prevention of wound infection in various types of hernia repair with mesh materials. METHODS: This is a prospective randomized control study. We evaluated wound infection rates in 395 patients with various kinds of hernia who underwent elective mesh repair using polypropylene mesh from 2007 to 2011. A total of 237 (60.0%) patients received prophylactic cefazolin (study group) and the remaining 158 (40.0%) patients did not receive any prophylactic antibiotics (control group). Patients were followed for infection at the following periods after the operation by an independent surgeon: 10 days, 30 days, 12 months, and then annually for at least 2 years. RESULTS: Eight (2.03%) patients had infection in the site of surgery [2 (1.27%) in the control group and 6 (2.53%) in the study group]. The distribution of infection was not significantly different between the two groups (p = 0.364). The superficial infections were managed by drainage and irrigation. One patient from the study group developed deep SSI and was readmitted and subsequently received antibiotic therapy, drainage, and debridement. CONCLUSION: Preoperative administration of single-dose cefazolin for prosthetic hernia repairs did not markedly decrease the risk of wound infection. Our results do not support the use of cefazolin as a prophylactic antibiotic for various kinds of abdominal wall hernia repair with mesh.
File Format	HTM / HTML
ISSN	10159584
e-ISSN	02193108
Journal	Asian Journal of Surgery
Issue Number	3
Volume Number	38
Language	English
Publisher	Elsevier
Publisher Date	2015-07-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline General Surgery Anti-bacterial Agents Therapeutic Use Cefazolin Hernia, Abdominal Surgery Herniorrhaphy Instrumentation Staphylococcal Infections Prevention & Control Surgical Mesh Surgical Wound Infection Antibiotic Prophylaxis Prospective Studies Etiology Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Surgery

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