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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Nusa, Roy Prasetyowati, Heni Meutiawati, Febrina Yohan, Benediktus Trimarsanto, Hidayat Setianingsih, Tri Yuli Sasmono, R. Tedjo |
Spatial Coverage | Indonesia |
Description | Country affiliation: Indonesia Author Affiliation: Nusa R ( Vector Borne Disease Control, Research and Development Council, Ministry of Health of the Republic of Indonesia, Ciamis, West Java, Indonesia. roynres@gmail.com.) |
Abstract | INTRODUCTION: Dengue is endemic and affects people in all Indonesian provinces. Increasing dengue cases have been observed every year in Sukabumi in West Java province. Despite the endemicity, limited data is available on the genetic of dengue viruses (DENV) circulating in the country. To understand the dynamics of dengue disease, we performed molecular and serological surveillance of dengue in Sukabumi. METHODOLOGY: A total of 113 patients were recruited for this study. Serological data were obtained using anti-dengue IgM and IgG tests plus dengue NS1 antigen detection. Dengue detection and serotyping were performed using real-time RT-PCR. Viruses were isolated and the envelope genes were sequenced. Phylogenetic and evolutionary analyses were performed to determine the genotype of the viruses and their evolutionary rates. RESULTS: Real-time RT-PCR detected DENV in 25 (22%) of 113 samples. Serotyping revealed the predominance of DENV-2 (16 isolates, 64%), followed by DENV-1 (5 isolates, 20%), and DENV-4 (4 isolates, 16%). No DENV-3 was detected in the samples. Co-circulation of genotype I and IV of DENV-1 was observed. The DENV-2 isolates all belonged to the Cosmopolitan genotype, while DENV-4 isolates were grouped into genotype II. Overall, their evolutionary rates were similar to DENV from other countries. CONCLUSIONS: We revealed the distribution of DENV serotypes and genotypes in Sukabumi. Compared to data obtained from other cities in Indonesia, we observed the differing predominance of DENV serotypes but similar genotype distribution, where the infecting viruses were closely related with Indonesian endemic viruses isolated previously. |
File Format | HTM / HTML |
ISSN | 20366590 |
Issue Number | 6 |
Volume Number | 8 |
e-ISSN | 19722680 |
Journal | The Journal of Infection in Developing Countries |
Language | English |
Publisher Date | 2014-06-11 |
Publisher Place | Italy |
Access Restriction | Subscribed |
Subject Keyword | Discipline Communicable Diseases Dengue Epidemiology Virology Endemic Diseases Adolescent Adult Aged Child Dengue Virus Classification Genetics Isolation & Purification Developing Countries Female Genes, Viral Humans Indonesia Male Middle Aged Molecular Epidemiology Rna, Viral Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Serotyping Young Adult Journal Article Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Eukaryota Viruses Virus Diseases Nucleic Acids, Nucleotides, and Nucleosides Diagnosis Investigative Techniques Genetic Phenomena Social Sciences Persons Environment and Public Health Geographic Locations |
Subject | Infectious Diseases Microbiology Virology Parasitology |
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