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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Komori, Hiroyuki Beppu, Toru Baba, Yoshifumi Horino, Kei Imsung, Choi Masuda, Toshiro Hayashi, Hiromitsu Okabe, Hirohisa Ootao, Ryuu Watanabe, Masayuki Takamori, Hiroshi Iyama, Kenichi Baba, Hideo |
Spatial Coverage | Japan |
Description | Country affiliation: Japan Author Affiliation: Komori H ( Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto, 860-8556, Japan.) |
Abstract | BACKGROUND: This study was performed to clarify the influence of preoperative chemotherapy on liver function and the correlation between histological hepatic injury and the postoperative outcome in patients with colorectal liver metastases who underwent a hepatic resection. METHODS: Twenty-seven patients who underwent a hepatic resection for colorectal liver metastases were included. Fifteen patients with initially unresectable colorectal liver metastases who were able to undergo a tumor resection after FOLFOX (oxaliplatin plus fluorouracil and leucovorin, with a mean number of 7.7 cycles) were compared to 12 patients who underwent a hepatectomy with no preoperative chemotherapy. The postoperative mortality, morbidity, changes in liver function tests, and pathology of the resected liver were examined. RESULTS: Preoperative FOLFOX therapy was significantly associated with the macroscopic appearance of oxaliplatin-associated blue liver (p = 0.02), and a tendency toward sinusoidal dilatation (33.3% in the FOLFOX group versus 8.3% in the no-chemotherapy group, p = 0.056). Preoperative liver function tests showed that the albumin and indocyanine green retention rate at 15 min (ICG-R15) test values were significantly worse after FOLFOX therapy; however, intraoperative events, postoperative liver function test values, and morbidity rates were similar in the two groups. There was no postoperative mortality in any of the patients. CONCLUSIONS: Although preoperative FOLFOX administration in patients with colorectal liver metastases caused macroscopic blue liver, microscopic sinusoidal dilatation in the liver parenchyma, and a significant decrease in liver function, there was no increase in the morbidity and mortality rates, in comparison to findings in patients without preoperative chemotherapy. |
File Format | HTM / HTML |
ISSN | 13419625 |
Issue Number | 3 |
Volume Number | 15 |
e-ISSN | 14377772 |
Journal | International Journal of Clinical Oncology |
Language | English |
Publisher | Springer |
Publisher Date | 2010-06-01 |
Publisher Place | Japan |
Access Restriction | Subscribed |
Subject Keyword | Discipline Oncology Antineoplastic Combined Chemotherapy Protocols Administration & Dosage Colorectal Neoplasms Pathology Hepatectomy Liver Neoplasms Drug Therapy Surgery Liver Drug Effects Adult Aged Aged, 80 And Over Adverse Effects Chemotherapy, Adjuvant Chi-square Distribution Dilatation, Pathologic Female Fluorouracil Humans Japan Leucovorin Physiopathology Liver Function Tests Secondary Male Middle Aged Neoadjuvant Therapy Organoplatinum Compounds Recovery Of Function Time Factors Treatment Outcome Journal Article |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Digestive System Eukaryota Neoplasms Pathological Conditions, Signs and Symptoms Organic Chemicals Heterocyclic Compounds Diagnosis Therapeutics Surgical Procedures, Operative Investigative Techniques Physical Phenomena Biological Phenomena Persons Geographic Locations |
Subject | Oncology Hematology Surgery |
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