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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Mouton, Julia Jansen, Olivia Frédérich, Michel Van Der Kooy, Frank |
Description | Country affiliation: Netherlands Author Affiliation: Mouton J ( Natural Products Laboratory, Institute of Biology, Leiden University, Leiden, the Netherlands.) |
Abstract | In our ongoing investigation into Artemisia annua for the treatment of malaria, we decided to study the possibility that synergism might enhance the efficacy of artemisinin. Our main objective was to test tea infusions and nonpolar extracts prepared from different A. annua varieties against Plasmodium falciparum in vitro in order to determine if synergism will increase the effectiveness of artemisinin in the samples as compared to pure artemisinin. We found that the IC50 of artemisinin in the tea and nonpolar extracts was not significantly different to the IC50 of pure artemisinin. We could show that the year and country of harvest or storage conditions did not have any influence on the activity and that it narrowly followed the concentration of artemisinin in all the extracts. In conclusion, based on these in vitro results, artemisinin seems to be the only active antiplasmodial compound in A. annua. |
File Format | HTM / HTML |
ISSN | 00320943 |
Issue Number | 6 |
Volume Number | 79 |
e-ISSN | 14390221 |
Journal | Planta Medica |
Language | English |
Publisher | George Thieme |
Publisher Date | 2013-04-01 |
Publisher Place | Germany |
Access Restriction | Subscribed |
Subject Keyword | Discipline Botany Antimalarials Pharmacology Artemisia Annua Chemistry Artemisinins Plant Extracts Plasmodium Falciparum Drug Effects Isolation & Purification Inhibitory Concentration 50 Journal Article Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Eukaryota Inorganic Chemicals Complex Mixtures Chemical Actions and Uses Investigative Techniques |
Subject | Complementary and Alternative Medicine Analytical Chemistry Drug Discovery Organic Chemistry Pharmacology Pharmaceutical Science Molecular Medicine |
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