NDLI: Gas chromatography-mass spectrometry of JWH-018 metabolites in urine samples with direct comparison to analytical standards.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Emerson, Beth Durham, Bill Gidden, Jennifer Lay, Jackson O.
Description	Country affiliation: United States Author Affiliation: Emerson B ( Department of Chemistry, University of Arkansas, Fayetteville, AR 72701, United States.)
Abstract	JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is one of numerous potential aminoalkylindoles contained in products marketed as 'K2' or 'Spice'. Investigation of the urinary metabolites from consumption of these compounds is important because they are banned in the United States and many European countries. An efficient extraction procedure and gas chromatography-mass spectrometry (GC-MS) method were developed for detection of 'K2' metabolites in urine from individuals suspected of using these products. Analytical standards were used to elucidate the structure-specific mass spectral fragmentations and retention properties to confirm proposed identifications and support quantitative studies. A procedure for the synthesis of one of these metabolites (5-hydroxypentyl JWH-018) was also developed. Results are comparable to existing LC-MS/MS methods, with the same primary metabolites detected. The specific metabolite hydrolysis products include 4-hydroxpentyl, 5-hydroxypentyl, and N-pentanoic acid derivatives.
File Format	HTM / HTML
ISSN	03790738
e-ISSN	18726283
DOI	10.1016/j.forsciint.2013.03.006
Journal	Forensic Science International
Issue Number	1-3
Volume Number	229
Language	English
Publisher	Elsevier
Publisher Date	2013-06-10
Publisher Place	Ireland
Access Restriction	Open
Subject Keyword	Urine Street Drugs Research Support, N.i.h., Extramural Discipline Forensic Science Pentanoic Acids Gas Chromatography-mass Spectrometry Solid Phase Extraction Indoles Substance Abuse Detection Naphthalenes
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine Law

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