NDLI: Seasonal fluctuations of glycated hemoglobin levels in Japanese diabetic patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sakura, Hiroshi Tanaka, Yasutomi Iwamoto, Yasuhiko
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Sakura H ( Diabetes Center, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. hsakura@dmc.twmu.ac.jp)
Abstract	AIMS: We examined whether glycated hemoglobin (HbA(1C)) levels of Japanese diabetic patients showed seasonal fluctuations. METHODS: Subjects included 2511 diabetic patients who regularly visited a single diabetic outpatient clinic for 10 years. A total of 253,477 HbA(1C) measurements, as well as sex, age, BMI, type of diabetes, and mode of therapy were extracted from a hospital-based database. For the cross-sectional and longitudinal analyses, average monthly HbA(1C) values of subjects and amplitudes of seasonal fluctuations were calculated. For the time-series analysis, seasonal adjustment factors of each subject were classified as complete, incomplete, or no fluctuation. RESULTS: Subjects showed a clear seasonal fluctuation of HbA(1C) levels, with highest levels in March (7.69%) and lowest levels in August (7.46%; p<0.001). The amplitudes of the seasonal fluctuations were associated with the mean HbA(1C) levels. The time-series analysis showed that 78.3% of patients had complete or incomplete seasonal fluctuations. HbA(1C) levels were highest in winter-spring and lowest in summer-autumn in most patients; however, some patients showed a reverse pattern. CONCLUSIONS: Seasonal fluctuations of HbA(1C) levels were recognized in most of the Japanese diabetic patients. Physiological or metabolic factors related to temperature may be the main cause of seasonal fluctuations in HbA(1C) levels.
File Format	HTM / HTML
ISSN	01688227
Issue Number	1
Volume Number	88
e-ISSN	18728227
Journal	Diabetes Research and Clinical Practice
Language	English
Publisher	Elsevier
Publisher Date	2010-04-01
Publisher Place	Ireland
Access Restriction	Subscribed
Subject Keyword	Research Support, Non-u.s. Gov't Cross-sectional Studies Hemoglobin A, Glycosylated Humans Japan Middle Aged Periodicity Blood Glucose Male Metabolism Aged, 80 And Over Blood Journal Article Asian Continental Ancestry Group Discipline Endocrinology Diabetes Mellitus, Type 1 Adult Female Diabetes Mellitus, Type 2 Aged Analysis Of Variance Databases, Factual
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Eukaryota Nutritional and Metabolic Diseases Carbohydrates Investigative Techniques Physical Phenomena Information Science Persons Geographic Locations
Subject	Endocrinology Internal Medicine Endocrinology, Diabetes and Metabolism

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