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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Kukreja, Sunil Ambekar, Sudheer Sharma, Mayur Sin, Anthony Hunkyun Nanda, Anil |
Description | Country affiliation: United States Author Affiliation: Kukreja S ( Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.); Ambekar S ( Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.); Sharma M ( Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.); Sin AH ( Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.); Nanda A ( Department of Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. Electronic address: ananda@lsuhsc.edu.) |
Abstract | OBJECTIVES: The results in earlier studies have described a variable association with age, extent of resection, and radiotherapy (RT) correlating with the survival of myxopapillary ependymomas. The aim of our study is to perform a survival analysis on patient data gathered from a comprehensive review of the literature and determine the influence of these factors on progression-free (PFS) and overall survival (OS). METHODS: A PubMed search was performed to select the articles containing information about the critical events (recurrence/death), time to events, and treatment characteristics (extent of resection with or without RT) in the patients with spinal myxopapillary ependymomas. RESULTS: A total of 337 patients with information regarding the critical events, time to events, and treatment characteristics was selected for the inclusion. Patients in gross-total resection group had better PFS and OS (P = 0.001, P = 0.000 respectively). The patients in older age group (>35 years) had better PFS (P = 0.008). Overall PFS did not improve if RT was combined with surgery compared with surgery alone; however, the adjuvant RT benefitted the patients age ≤35 years. RT dose >50 Gy had significant influence on the PFS (P = 0.034). CONCLUSION: Gross-total resection plays the most important role in improving PFS and OS. Older patients had better PFS; however, the influence of adjuvant RT was significant in younger age groups. A dose of >50 Gy improves the results, but a randomized controlled study is warranted to arrive at a definite conclusion. |
File Format | HTM / HTML |
ISSN | 18788750 |
Issue Number | 5 |
Volume Number | 83 |
e-ISSN | 18788769 |
Journal | World Neurosurgery |
Language | English |
Publisher | Elsevier |
Publisher Date | 2015-05-01 |
Publisher Place | United States |
Access Restriction | Subscribed |
Subject Keyword | Discipline Neurosurgery Ependymoma Surgery Spinal Cord Neoplasms Age Factors Combined Modality Therapy Disease-free Survival Radiotherapy Humans Predictive Value Of Tests Prognosis Survival Analysis Treatment Outcome Journal Article Meta-analysis Review |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Eukaryota Neoplasms Diagnosis Therapeutics Investigative Techniques Health Care Quality, Access, and Evaluation |
Subject | Neurology (clinical) Surgery |
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