NDLI: The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ye, Jun Wu, Dang Wu, Pin Chen, Zhigang Huang, Jian
Description	Country affiliation: China Author Affiliation: Ye J ( Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.)
Abstract	Despite recent progresses in tumor therapy and increased knowledge in tumor biology, tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a subset of cancer cells with a stem cell-like ability, which may drive tumor growth and recurrence and are resistant to many current anticancer treatments. Solid tumors are regarded as 'organs' which are comprised of cancer cells and the tumor stroma. The tumor microenvironment makes up the stroma of the tumor, which occupies the majority of the tumor mass, including the extracellular matrix (ECM), mesenchymal stem cells (MSCs), endothelial cells, immune cells, and, what is more, networks of cytokines and growth factors. The microenvironment or niche surrounding CSCs largely governs their cellular fate. Recent work has revealed that the microenvironment supports CSC self-renewal and simultaneously serves as a physical barrier to drug delivery. The tumor microenvironment plays pivotal roles in each stage of tumor development. Knowledge about the interactions of CSCs with their microenvironment would seem to be of most importance for developing new treatment strategies.
File Format	HTM / HTML
ISSN	10104283
Issue Number	5
Volume Number	35
e-ISSN	14230380
Journal	Tumor Biology
Language	English
Publisher	Springer
Publisher Date	2014-05-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Medicine__semicolon__oncology Neoplasms Etiology Neoplastic Stem Cells Physiology Tumor Microenvironment Animals Cell Hypoxia Cytokines Epithelial-mesenchymal Transition Exosomes Extracellular Matrix Humans Hypoxia-inducible Factor 1, Alpha Subunit Physiopathology Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Cells Eukaryota Neoplasms Amino Acids, Peptides, and Proteins Metabolism Cell Physiological Phenomena
Subject	Cancer Research Medicine

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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