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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Mizumoto, Masashi Okumura, Toshiyuki Hashimoto, Takayuki Fukuda, Kuniaki Oshiro, Yoshiko Fukumitsu, Nobuyoshi Abei, Masato Kawaguchi, Atsushi Hayashi, Yasutaka Ohkawa, Ayako Hashii, Haruko Kanemoto, Ayae Moritake, Takashi Tohno, Eriko Tsuboi, Koji Sakae, Takeji Sakurai, Hideyuki |
Description | Country affiliation: Japan Author Affiliation: Mizumoto M ( Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.) |
Abstract | PURPOSE: Our previous results for treatment of hepatocellular carcinoma with proton beam therapy (PBT) revealed excellent local control. In this study, we focused on the impact of PBT on normal liver function. METHODS AND MATERIALS: The subjects were 259 patients treated with PBT at the University of Tsukuba between January 2001 and December 2007. We evaluated the Child-Pugh score pretreatment, on the final day of PBT, and 6, 12, and 24 months after treatment with PBT. Patients who had disease progression or who died with tumor progression at each evaluation point were excluded from the analysis to rule out an effect of tumor progression. An increase in the Child-Pugh score of 1 or more was defined as an adverse event. RESULTS: Of the 259 patients, 241 had no disease progression on the final day of PBT, and 91 had no progression within 12 months after PBT. In univariate analysis, the percentage volumes of normal liver receiving at least 0, 10, 20, and 30 GyE in PBT (V0, 10, 20, and 30) were significantly associated with an increase of Child-Pugh score at 12 months after PBT. Of the 91 patients evaluated at 12 months, 66 had no increase of Child-Pugh score, 15 had a 1-point increase, and 10 had an increase of ≥2 points. For the Youden index, the optimal cut-offs for V0, V10, V20, and V30 were 30%, 20%, 26%, and 18%, respectively. CONCLUSION: Our findings indicate that liver function after PBT is significantly related to the percentage volume of normal liver that is not irradiated. This suggests that further study of the relationship between liver function and PBT is required. |
File Format | HTM / HTML |
ISSN | 03603016 |
Issue Number | 3 |
Volume Number | 82 |
e-ISSN | 1879355X |
Journal | International Journal of Radiation OncologyastBiologyastPhysics |
Language | English |
Publisher | Elsevier |
Publisher Date | 2012-03-01 |
Publisher Place | United States |
Access Restriction | Subscribed |
Subject Keyword | Discipline Radiology Carcinoma, Hepatocellular Radiotherapy Liver Neoplasms Liver Radiation Effects Protons Therapeutic Use Adult Aged Aged, 80 And Over Analysis Of Variance Physiopathology Disease Progression Female Humans Physiology Liver Failure Etiology Male Middle Aged Prognosis Retrospective Studies Journal Article Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Digestive System Eukaryota Neoplasms Digestive System Diseases Pathological Conditions, Signs and Symptoms Inorganic Chemicals Diagnosis Investigative Techniques Persons |
Subject | Oncology Radiology, Nuclear Medicine and Imaging Cancer Research Radiation |
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