NDLI: Gas phase H/D exchange kinetics: DI versus D$

Content Provider	SpringerLink
Author	Schaaff, T. Gregory Stephenson, James L. McLuckey, Scott A.
Copyright Year	2000
Abstract	The gas phase H/D exchange reactions of bradykinin (M + 3H)$^{3+}$ ions with D$_{2}$O and DI were monitored in a quadrupole ion trap mass spectrometer. The H/D exchange kinetics of both chemical probes (D$_{2}$O and DI) indicate the presence of two noninterconverting reactive gas phase ion populations of bradykinin (M + 3H)$^{3+}$ at room temperature. The H/D exchange involving DI, however, generally proceeds faster than that involving D$_{2}$O. The rate observations described here can be rationalized on the basis of the “relay mechanism” (see Campbell et al. J. Am. Chem. Soc. 1995, 117, 12840–12854) recently proposed to account for H/D exchange between D$_{2}$O and gaseous protonated polypeptides. The higher exchange rate with DI is believed to arise primarily as a result of its lower gas-phase acidity relative to that of D$_{2}$O and, secondarily, as a result of the longer bond length of DI relative to that of OD in D$_{2}$O.
Starting Page	167
Ending Page	171
Page Count	5
File Format	PDF
ISSN	10440305
Journal	Journal of The American Society for Mass Spectrometry
Volume Number	11
Issue Number	2
e-ISSN	18791123
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-01-01
Publisher Institution	The American Society for Mass Spectrometry
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Analytical Chemistry Biotechnology Organic Chemistry Proteomics Bioinformatics
Content Type	Text
Resource Type	Article
Subject	Structural Biology Spectroscopy

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