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  1. Journal of Wuhan University of Technology-Mater. Sci. Ed.
  2. Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24
  3. Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 4, August 2009
  4. Evaluation of PLGA/chitosan/HA conduits for nerve tissue reconstruction
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Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 32
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 31
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 30
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 29
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 28
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 27
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 26
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 25
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 6, December 2009
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 5, October 2009
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 4, August 2009
Surface nanocrystallization of magnesium alloy AZ91D by high-energy shot peening
Preparation and characteristic of self-regulation water-transmitting coating fiber
The film-forming behavior on the interface between air and hydrosol of Fe$_{2}$O$_{3}$ nanoparticles
Microstrain in nanocrystalline copper by high resolution electron microscopy
Effect of pH values on photocatalytic properties of Bi$_{2}$WO$_{6}$ synthesized by hydrothermal method
Effect of additives on the sintering of amorphous nano-sized silicon nitride powders
Preparation and activity of a nanometer anti-microbial polyurethane
Influence of acetic acid on dynamic behavior of hydrolazation and film forming of organosilane
Preparation and electrochemical studies of Y-doped LiVPO$_{4}$F cathode materials for lithium-ion batteries
Disruption of bacterial cells by photocatalysis of montmorillonite supported titanium dioxide
Preparation and characterization of polylactide/montmorillonite nanocomposites
Evaluation of PLGA/chitosan/HA conduits for nerve tissue reconstruction
Poly(N-isopropylacrylamide), poly(methacrylic acid) and their copolymers for oral colon-specific drug delivery
Rheological properties of konjac glucomannan/SiO$_{2}$/organic-borate gels
Mechanical and thermal properties of muscovite and density polyethylene-reinforced and -toughened polypropylene composites
A comparative study of tribological properties between perfluoro and non-perfluoro alkylsilane self-assembled monolayers(SAMs)
Synthesis and characterization of soluble aromatic azopolyamides containing sulfone and ether units
Electronic structure of SiC (310) twin boundary doped with B, N, Al and Ti
Separation of red (Y$_{2}$O$_{3}$:Eu$^{3+}$), blue (BaMgAl$_{10}$O$_{17}$:Eu$^{2+}$) and green (CeMgAl$_{10}$O$_{17}$:Tb$^{3}$) rare earth phosphors by liquid/liquid extraction
Determination of trace elements in high purity gold by high resolution inductively coupled plasma mass spectrometry
Synthesis and characteristics of mesoporous silica aerogels with one-step solvent exchange/surface modification
Physiochemical and biological properties of modified collagen sponge from porcine skin
Toughening modification of unsaturated polyester resin using HDI trimer
Preparation of self-crosslinked fluorocarbon polymer emulsion with core-shell structure by the method of soap-free emulsion polymerization
Preparation of core-shell Cu-Ag bimetallic powder via electroless coating
Glass-forming ability and chemical stability of magneto-optical glass heavily doped with rare earth oxide
Synthesis of the novel fluoride-containing organic silane
Glass-coated individual dispersed MWNTs in Alumina & its high temperature stability
Molten salts/ceramic-foam matrix composites by melt infiltration method as energy storage material
Synthesis and characterization of ibuprofen-rectorite composites by solution intercalation method
Effect of nucleating agent on the crystallization of tailings glass ceramics prepared by one-time sintering
Carbonation resistance of sulphoaluminate cement-based high performance concrete
The future resources for eco-building materials: II. Fly ash and coal waste
Effect of organophilic montmorillonite on thermal-oxidative aging behavior of SBS modified bitumen crack filling material
Tensile and flexural properties of ultra high toughness cemontious composite
Self similarity of the spherical C-S-H particle in cement paste
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 3, June 2009
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 2, April 2009
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 24, Issue 1, February 2009
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 23
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 22
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 21
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 20
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 19
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 18
Journal of Wuhan University of Technology-Mater. Sci. Ed. : Volume 17

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Evaluation of PLGA/chitosan/HA conduits for nerve tissue reconstruction

Content Provider SpringerLink
Author Shen, Xiongjun Ruan, Jianming Zhou, Zhongchi Zeng, Zhicheng Xie, Lesi
Copyright Year 2009
Abstract A micro-envioment for nerve cells and tissue growth were designed and constructed via surface modification of poly(L-lactide-co-glycolide)(PLGA) with chitosan and hydroxyapatite(HA). The poly(L-lactide-co-glycolide)/chitosan/hydroxyapatite (PLGA/chitosan/HA) conduits were manufactured by a combined solvent casting and particulate leaching technique. The conduits were highly porous with an interconnected pore structure and 76.5% porosity. Micropores with 50–100 micrometer diameter were formed in the conduits. In vivo application of PLGA/chitosan/HA conduits for reconstruction of 10 mm sciatic nerve defect was assessed by the walking track analysis, the quantifying of the wet weight of tibialis anterior muscle and the histological assessment. The conduits in host rats in vivo can not only be an effective in promoting regenerating of nerves but can also lead to favorable nerve functional recovery.
Starting Page 566
Ending Page 570
Page Count 5
File Format PDF
ISSN 10002413
Journal Journal of Wuhan University of Technology-Mater. Sci. Ed.
Volume Number 24
Issue Number 4
e-ISSN 19930437
Language English
Publisher Wuhan University of Technology
Publisher Date 2009-07-22
Publisher Place Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword poly(L-lactide-co-glycolide)/chitosan/hydroxyapatite(PLGA/chitosan/HA) conduit biocompatibility nerve regeneration tissue engineering Materials Science
Content Type Text
Resource Type Article
Subject Materials Science
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