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  1. Medical and Biological Engineering and Computing
  2. Medical and Biological Engineering and Computing : Volume 43
  3. Medical and Biological Engineering and Computing : Volume 43, Issue 5, October 2005
  4. Simulation of intra-orbital optic nerve electrical stimulation
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Medical and Biological Engineering and Computing : Volume 55
Medical and Biological Engineering and Computing : Volume 54
Medical and Biological Engineering and Computing : Volume 53
Medical and Biological Engineering and Computing : Volume 52
Medical and Biological Engineering and Computing : Volume 51
Medical and Biological Engineering and Computing : Volume 50
Medical and Biological Engineering and Computing : Volume 49
Medical and Biological Engineering and Computing : Volume 48
Medical and Biological Engineering and Computing : Volume 47
Medical and Biological Engineering and Computing : Volume 46
Medical and Biological Engineering and Computing : Volume 45
Medical and Biological Engineering and Computing : Volume 44
Medical and Biological Engineering and Computing : Volume 43
Medical and Biological Engineering and Computing : Volume 43, Issue 6, November 2005
Medical and Biological Engineering and Computing : Volume 43, Issue 5, October 2005
Evaluation of antidecubitus mattresses
Evaluation of a fall detector based on accelerometers: A pilot study
Instrumented staircase for kinetic analyses of upper-and lower-limb function during stair gait
Estimation of atrial fibrillatory wave from single-lead atrial fibrillation electrocardiograms using principal component analysis concepts
Atrial cell action potential parameter fitting using genetic algorithms
Suppression of the cardiac electric field artifact from the heart action evoked potential
Myocardial perfusion monitoring during coronary artery bypass using an electrocardiogram-triggered laser Doppler technique
Robust and self-tuning blood flow control during extracorporeal circulation in the presence of system parameter uncertainties
Amplitude and phase relationship between alpha and beta oscillations in the human electroencephalogram
Simulation of intra-orbital optic nerve electrical stimulation
Noise from implantable Cooper cable
Lidocaine transport through living rat skin using alternating current
Reduction of noise from magnetoencephalography data
Adaptive filtering of evoked potentials using higher-order adaptive signal enhancer with genetic-type variable step-size prefilter
Genetic algorithm for the efficient selection of disyllabic word lists used in Mandarin speech discrimination tests
In vitro measurements of optical properties of porcine brain using a novel compact device
CT—3D rotational angiography automatic registration: A sensitivity analysis
Automatic analysis of immunocytochemically stained tissue samples
Parametric image of myocardial blood flow generated from dynamic H$_{2}$ $^{15}$O PET using factor analysis and cluster analysis
Design and validation of an analyser to measure sulphur hexafluoride gas during respiration
Medical and Biological Engineering and Computing : Volume 43, Issue 4, August 2005
Medical and Biological Engineering and Computing : Volume 43, Issue 3, June 2005
Medical and Biological Engineering and Computing : Volume 43, Issue 2, April 2005
Medical and Biological Engineering and Computing : Volume 43, Issue 1, February 2005
Medical and Biological Engineering and Computing : Volume 42
Medical and Biological Engineering and Computing : Volume 41
Medical and Biological Engineering and Computing : Volume 40
Medical and Biological Engineering and Computing : Volume 39
Medical and Biological Engineering and Computing : Volume 38
Medical and Biological Engineering and Computing : Volume 37
Medical and Biological Engineering and Computing : Volume 36
Medical and Biological Engineering and Computing : Volume 35

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Simulation of intra-orbital optic nerve electrical stimulation

Content Provider SpringerLink
Author Oozeer, M. Veraart, C. Legat, V. Delbeke, J.
Copyright Year 2005
Abstract In blind subjects who still have functional retinal ganglion cells, electrical stimuli applied to the optic nerve can produce localised visual sensations. This has been demonstrated with an intracranially implanted self-sizing spiral cuff electrode, but, to avoid skull opening, intra-orbital cuff implantation is now considered. In its orbital segment, the optic nerve is surrounded by subarachnoidal cerebrospinal fluid (CSF) and dura mater. Dura mater is a tough fibrous tissue that can impede electrical stimulation. In the study, the issue of whether or not to remove the dura mater at the implantation site was addressed using simulation on numerical models. Several volume conductor models were built representing, respectively: the cuff implanted directly around the nerve; the cuff over the nerve after connective tissue encapsulated the implant; and the cuff electrode placed around the dura mater. Stimulation-induced electric potential fields were computed for these configurations using a full 3D finite elements software. Responses of fibres within the nerve were computed. A large range of dural conductivities and several CSF thicknesses were considered. In all simulated conditions, the presence of dura mater around a layer of CSF increased excitation thresholds. Selectivity performance also decreased, but was found to be independent of the CSF thickness. However, simulations showed that, if the diameter of the cuff electrode is adapted to the target nerve, the injected charge associated with activation is limited within a reasonable range. Electrical stimulation of the optic nerve with a cuff electrode implanted around the dura mater should therefore be feasible.
Starting Page 608
Ending Page 617
Page Count 10
File Format PDF
ISSN 01400118
Journal Medical and Biological Engineering and Computing
Volume Number 43
Issue Number 5
e-ISSN 17410444
Language English
Publisher Springer-Verlag
Publisher Date 2005-01-01
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Intraorbital optic nerve Cuff electrode Visual prosthesis Finite element method Functional electrical stimulation Human Physiology Computer Applications Neurosciences Imaging Radiology Biomedical Engineering
Content Type Text
Resource Type Article
Subject Biomedical Engineering Computer Science Applications
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