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  1. Journal of Pharmacokinetics and Pharmacodynamics
  2. Journal of Pharmacokinetics and Pharmacodynamics : Volume 43
  3. Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 1, February 2016
  4. What do we mean by identifiability in mixed effects models?
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Journal of Pharmacokinetics and Pharmacodynamics : Volume 44
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 6, December 2016
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 5, October 2016
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 1, Supplement,October 2016
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 4, August 2016
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 3, June 2016
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 2, April 2016
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43, Issue 1, February 2016
Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist
Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment
Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment
Improvement in latent variable indirect response joint modeling of a continuous and a categorical clinical endpoint in rheumatoid arthritis
Erratum to: Improvement in latent variable indirect response joint modeling of a continuous and a categorical clinical endpoint in rheumatoid arthritis
Application of a hazard-based visual predictive check to evaluate parametric hazard models
Population pharmacokinetics of ramosetron
Stochastic nonlinear mixed effects: a metformin case study
A population pharmacokinetic model for R- and S-citalopram and desmethylcitalopram in Alzheimer’s disease patients with agitation
What do we mean by identifiability in mixed effects models?
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42
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Journal of Pharmacokinetics and Pharmacodynamics : Volume 36
Journal of Pharmacokinetics and Pharmacodynamics : Volume 35
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Journal of Pharmacokinetics and Pharmacodynamics : Volume 33
Journal of Pharmacokinetics and Pharmacodynamics : Volume 32
Journal of Pharmacokinetics and Pharmacodynamics : Volume 31
Journal of Pharmacokinetics and Pharmacodynamics : Volume 30
Journal of Pharmacokinetics and Pharmacodynamics : Volume 29
Journal of Pharmacokinetics and Pharmacodynamics : Volume 28
Journal of Pharmacokinetics and Pharmacodynamics : Volume 27
Journal of Pharmacokinetics and Pharmacodynamics : Volume 26
Journal of Pharmacokinetics and Pharmacodynamics : Volume 25

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What do we mean by identifiability in mixed effects models?

Content Provider SpringerLink
Author Lavielle, Marc Aarons, Leon
Copyright Year 2015
Abstract We discuss the question of model identifiability within the context of nonlinear mixed effects models. Although there has been extensive research in the area of fixed effects models, much less attention has been paid to random effects models. In this context we distinguish between theoretical identifiability, in which different parameter values lead to non-identical probability distributions, structural identifiability which concerns the algebraic properties of the structural model, and practical identifiability, whereby the model may be theoretically identifiable but the design of the experiment may make parameter estimation difficult and imprecise. We explore a number of pharmacokinetic models which are known to be non-identifiable at an individual level but can become identifiable at the population level if a number of specific assumptions on the probabilistic model hold. Essentially if the probabilistic models are different, even though the structural models are non-identifiable, then they will lead to different likelihoods. The findings are supported through simulations.
Starting Page 111
Ending Page 122
Page Count 12
File Format PDF
ISSN 1567567X
Journal Journal of Pharmacokinetics and Pharmacodynamics
Volume Number 43
Issue Number 1
e-ISSN 15738744
Language English
Publisher Springer US
Publisher Date 2015-12-10
Publisher Place New York
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Model identifiability Practical identifiability Structural identifiability Parameter estimation Mixed effects model Pharmacokinetics Pharmacology/Toxicology Pharmacy Veterinary Medicine Biomedical Engineering Biochemistry
Content Type Text
Resource Type Article
Subject Pharmacology
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