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  1. Journal of Pharmacokinetics and Pharmacodynamics
  2. Journal of Pharmacokinetics and Pharmacodynamics : Volume 38
  3. Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 6, December 2011
  4. Modeling red blood cell survival data
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Journal of Pharmacokinetics and Pharmacodynamics : Volume 44
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42
Journal of Pharmacokinetics and Pharmacodynamics : Volume 41
Journal of Pharmacokinetics and Pharmacodynamics : Volume 40
Journal of Pharmacokinetics and Pharmacodynamics : Volume 39
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 6, December 2011
Evaluation of false positive rate based on exposure–response analyses for two compounds in fixed-dose combination products
A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat
Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test
Non-linear mixed effects modeling of antiretroviral drug response after administration of lopinavir, atazanavir and efavirenz containing regimens to treatment-naïve HIV-1 infected patients
The influence of distributional kinetics into a peripheral compartment on the pharmacokinetics of substrate partitioning between blood and brain tissue
Population pharmacokinetic–pharmacodynamic–disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis
Modeling red blood cell survival data
Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients
Extending the latent variable model for extra correlated longitudinal dichotomous responses
Automatic data binning for improved visual diagnosis of pharmacometric models
Coping with time scales in disease systems analysis: application to bone remodeling
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 5, October 2011
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 4, August 2011
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 3, June 2011
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 2, April 2011
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38, Issue 1, February 2011
Journal of Pharmacokinetics and Pharmacodynamics : Volume 37
Journal of Pharmacokinetics and Pharmacodynamics : Volume 36
Journal of Pharmacokinetics and Pharmacodynamics : Volume 35
Journal of Pharmacokinetics and Pharmacodynamics : Volume 34
Journal of Pharmacokinetics and Pharmacodynamics : Volume 33
Journal of Pharmacokinetics and Pharmacodynamics : Volume 32
Journal of Pharmacokinetics and Pharmacodynamics : Volume 31
Journal of Pharmacokinetics and Pharmacodynamics : Volume 30
Journal of Pharmacokinetics and Pharmacodynamics : Volume 29
Journal of Pharmacokinetics and Pharmacodynamics : Volume 28
Journal of Pharmacokinetics and Pharmacodynamics : Volume 27
Journal of Pharmacokinetics and Pharmacodynamics : Volume 26
Journal of Pharmacokinetics and Pharmacodynamics : Volume 25

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Modeling red blood cell survival data

Content Provider SpringerLink
Author Korell, Julia Vos, Frederiek E. Coulter, Carolyn V. Schollum, John B. Walker, Robert J. Duffull, Stephen B.
Copyright Year 2011
Abstract Anaemia of chronic kidney disease (CKD) is a common complication in patients with renal impairment, especially in end-stage renal failure. As well as erythropoietin deficiency, decreased red blood cell survival is a contributing factor. However, it remains unclear which mechanism underlies the altered survival of red blood cells (RBCs). In this work a previously developed statistical model for RBC survival was applied to clinical data obtained from 14 patients with CKD undergoing hemodialysis as well as 14 healthy controls using radioactive chromium ($^{51}$Cr) as random labelling method. A classical two-stage approach and a full population analysis were applied to estimate the key parameters controlling random destruction and senescence in the model. Estimating random destruction was preferred over estimating an accelerated senescence in both approaches and both groups as it provided the better fit to the data. Due to significant nonspecific random loss of the label from the cells that cannot be quantified directly only a relative RBC survival can be obtained from data using $^{51}$Cr as labelling method. Nevertheless, RBC survival was found to be significantly reduced in CKD patients compared to the controls with a relative reduction of 20–30% depending on the analysis method used.
Starting Page 787
Ending Page 801
Page Count 15
File Format PDF
ISSN 1567567X
Journal Journal of Pharmacokinetics and Pharmacodynamics
Volume Number 38
Issue Number 6
e-ISSN 15738744
Language English
Publisher Springer US
Publisher Date 2011-10-14
Publisher Place Boston
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Red blood cells Lifespan Random destruction Senescence Radioactive chromium Chronic kidney disease Hemodialysis Two-stage approach Population approach MONOLIX Biomedical Engineering Pharmacy Pharmacology/Toxicology Veterinary Medicine Biochemistry
Content Type Text
Resource Type Article
Subject Pharmacology
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