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  1. Journal of Pharmacokinetics and Pharmacodynamics
  2. Journal of Pharmacokinetics and Pharmacodynamics : Volume 42
  3. Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 5, October 2015
  4. Pharmacodynamic models of age-structured cell populations
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Journal of Pharmacokinetics and Pharmacodynamics : Volume 44
Journal of Pharmacokinetics and Pharmacodynamics : Volume 43
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 6, December 2015
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 5, October 2015
Preface to the special issue to honor Gerhard Levy and 50 years of PK/PD
Perspectives on the history and scientific contributions of Gerhard Levy
Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models
Prediction and validation of enzyme and transporter off-targets for metformin
Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells
Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and l-lactate in rats
Bayesian population modeling of drug dosing adherence
Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys
Physiologically-based pharmacokinetic modeling of target-mediated drug disposition of bortezomib in mice
Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics
Pharmacodynamic models of age-structured cell populations
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 1, Supplement,October 2015
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 4, August 2015
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 3, June 2015
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 2, April 2015
Journal of Pharmacokinetics and Pharmacodynamics : Volume 42, Issue 1, February 2015
Journal of Pharmacokinetics and Pharmacodynamics : Volume 41
Journal of Pharmacokinetics and Pharmacodynamics : Volume 40
Journal of Pharmacokinetics and Pharmacodynamics : Volume 39
Journal of Pharmacokinetics and Pharmacodynamics : Volume 38
Journal of Pharmacokinetics and Pharmacodynamics : Volume 37
Journal of Pharmacokinetics and Pharmacodynamics : Volume 36
Journal of Pharmacokinetics and Pharmacodynamics : Volume 35
Journal of Pharmacokinetics and Pharmacodynamics : Volume 34
Journal of Pharmacokinetics and Pharmacodynamics : Volume 33
Journal of Pharmacokinetics and Pharmacodynamics : Volume 32
Journal of Pharmacokinetics and Pharmacodynamics : Volume 31
Journal of Pharmacokinetics and Pharmacodynamics : Volume 30
Journal of Pharmacokinetics and Pharmacodynamics : Volume 29
Journal of Pharmacokinetics and Pharmacodynamics : Volume 28
Journal of Pharmacokinetics and Pharmacodynamics : Volume 27
Journal of Pharmacokinetics and Pharmacodynamics : Volume 26
Journal of Pharmacokinetics and Pharmacodynamics : Volume 25

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Pharmacodynamic models of age-structured cell populations

Content Provider SpringerLink
Author Krzyzanski, Wojciech
Copyright Year 2015
Abstract The purpose of this work is to review basic pharmacodynamic (PD) models describing drug effects on cell populations and expand them to age-structured models using the theory of physiologically structured populations. The plasma drug concentrations are interpreted as the environment affecting the cell production and mortality rates. An explicit solution to model equations provides the age density distribution that serves to establish a relationship between the cell lifespan distribution and the hazard of cell removal. Given the lifespan distributions, the age distributions for most commonly applied PD models of cell responses including basic cell turnover, transit compartments, and basic lifespan models have been derived both for the baseline conditions and drug treatment. The steady-state age distribution for basic indirect response models is exponential, and it is uniform for the basic lifespan model. As an example of more complex cell population, the age distribution of human red blood cells has been simulated based on a recent model of red blood cell survival. The age distribution for cells in the transit compartment model is the sum of the gamma functions. Means and variances of age distributions for all discussed models were calculated. A brief discussion of numerical challenges and possible future model developments is presented.
Starting Page 573
Ending Page 589
Page Count 17
File Format PDF
ISSN 1567567X
Journal Journal of Pharmacokinetics and Pharmacodynamics
Volume Number 42
Issue Number 5
e-ISSN 15738744
Language English
Publisher Springer US
Publisher Date 2015-09-16
Publisher Place New York
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Cell population Age structure Pharmacodynamic model Mortality rate Lifespan distribution Pharmacology/Toxicology Pharmacy Veterinary Medicine Biomedical Engineering Biochemistry
Content Type Text
Resource Type Article
Subject Pharmacology
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