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  1. Archives of Environmental Contamination and Toxicology
  2. Archives of Environmental Contamination and Toxicology : Volume 49
  3. Archives of Environmental Contamination and Toxicology : Volume 49, Issue 1, July 2005
  4. Effects of N-Acetylcysteine on Lead-Exposed PC-12 Cells
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Archives of Environmental Contamination and Toxicology : Volume 72
Archives of Environmental Contamination and Toxicology : Volume 71
Archives of Environmental Contamination and Toxicology : Volume 70
Archives of Environmental Contamination and Toxicology : Volume 69
Archives of Environmental Contamination and Toxicology : Volume 68
Archives of Environmental Contamination and Toxicology : Volume 67
Archives of Environmental Contamination and Toxicology : Volume 66
Archives of Environmental Contamination and Toxicology : Volume 65
Archives of Environmental Contamination and Toxicology : Volume 64
Archives of Environmental Contamination and Toxicology : Volume 63
Archives of Environmental Contamination and Toxicology : Volume 62
Archives of Environmental Contamination and Toxicology : Volume 61
Archives of Environmental Contamination and Toxicology : Volume 60
Archives of Environmental Contamination and Toxicology : Volume 59
Archives of Environmental Contamination and Toxicology : Volume 58
Archives of Environmental Contamination and Toxicology : Volume 57
Archives of Environmental Contamination and Toxicology : Volume 56
Archives of Environmental Contamination and Toxicology : Volume 55
Archives of Environmental Contamination and Toxicology : Volume 54
Archives of Environmental Contamination and Toxicology : Volume 53
Archives of Environmental Contamination and Toxicology : Volume 52
Archives of Environmental Contamination and Toxicology : Volume 51
Archives of Environmental Contamination and Toxicology : Volume 50
Archives of Environmental Contamination and Toxicology : Volume 49
Archives of Environmental Contamination and Toxicology : Volume 49, Issue 4, November 2005
Archives of Environmental Contamination and Toxicology : Volume 49, Issue 3, October 2005
Archives of Environmental Contamination and Toxicology : Volume 49, Issue 2, August 2005
Archives of Environmental Contamination and Toxicology : Volume 49, Issue 1, July 2005
The Ratios of Individual Chemicals in a Mixture Determine the Degree of Joint Effect: The Climax Hypothesis
Fate of Triclosan and Triclosan-Methyl in Sewage TreatmentPlants and Surface Waters
Toxicological Guidelines for Monocyclic Nitro-, Amino- and Aminonitroaromatics, Nitramines, and Nitrate Esters in Drinking Water
Kinetics of Degradation of Hydrocarbons in the Contaminated Soil Layer
Residues of Organic Chlorinated Pesticides in Agricultural Soils of Beijing, China
Quantitative Ultrastructure of Metal-Sequestering Cells Reflects Intersite and Interspecies Differences in Earthworm Metal Burdens
Endocrine Effects in Gammarus fossarum (Amphipoda): Influence of Wastewater Effluents, Temporal Variability, and Spatial Aspects on Natural Populations
Seasonal Variability of Metallothioneins, Cytochrome P450, Bile Metabolites and Oxyradical Metabolism in the European Eel Anguilla anguilla L. (Anguillidae) and Striped Mullet Mugil cephalus L. (Mugilidae)
Effects of Dietary Selenomethionine on Larval Rainbow Trout (Oncorhynchus mykiss)
Concentrations of Cadmium, Lead, and Zinc in Fish from Mining-Influenced Waters of Northeastern Oklahoma: Sampling of Blood, Carcass, and Liver for Aquatic Biomonitoring
Chlorinated Hydrocarbon Contaminants and Stable Isotope Ratios in Pelagic Seabirds From the North Pacific Ocean
Lead Concentrations in Ruffed Grouse, Rock Ptarmigan, and Willow Ptarmiganin Québec
Time- and Tissue-Dependent Polychlorinated Biphenyl Residues in Hairless Mice After Exposure to Polychlorinated Biphenyl-Contaminated Soil
Effects of N-Acetylcysteine on Lead-Exposed PC-12 Cells
Survey of Human Exposure to PCDDs, PCDFs, and Coplanar PCBs Using Hairas an Indicator
Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Coplanar Polychlorinated Biphenyls in Human Milk in Osaka City, Japan
Archives of Environmental Contamination and Toxicology : Volume 48
Archives of Environmental Contamination and Toxicology : Volume 47
Archives of Environmental Contamination and Toxicology : Volume 46
Archives of Environmental Contamination and Toxicology : Volume 45
Archives of Environmental Contamination and Toxicology : Volume 44
Archives of Environmental Contamination and Toxicology : Volume 43
Archives of Environmental Contamination and Toxicology : Volume 42
Archives of Environmental Contamination and Toxicology : Volume 41
Archives of Environmental Contamination and Toxicology : Volume 40
Archives of Environmental Contamination and Toxicology : Volume 39
Archives of Environmental Contamination and Toxicology : Volume 38
Archives of Environmental Contamination and Toxicology : Volume 37
Archives of Environmental Contamination and Toxicology : Volume 36
Archives of Environmental Contamination and Toxicology : Volume 35
Archives of Environmental Contamination and Toxicology : Volume 34
Archives of Environmental Contamination and Toxicology : Volume 33
Archives of Environmental Contamination and Toxicology : Volume 32

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Effects of N-Acetylcysteine on Lead-Exposed PC-12 Cells

Content Provider SpringerLink
Author Aykin Burns, Nukhet Franklin, Elizabeth A. Ercal, Nuran
Copyright Year 2005
Abstract The neurotoxicity of lead has been well established through numerous studies. However, the cellular processes of lead neurotoxicity, as well as techniques to prevent or reverse cellular damage after lead exposure, remain unknown. If oxidative stress plays a primary role in lead-induced neurotoxicity, antioxidants should assist in reviving lead-exposed cells. The present study explores N-acetylcysteine (NAC) as an antioxidant agent in PC-12 cells after lead exposure. Selective oxidative stress parameters, including glutathione (GSH), glutathione disulfide (GSSG), and malondialdehyde (MDA), were measured in PC-12 cells exposed to various concentrations of lead acetate. Administering NAC after lead exposure improved cell survival as measured by Trypan Blue exclusion. NAC treatment also increased the GSH/GSSG ratio compared to the lead-only group, and reduced MDA to near control levels. These results imply that NAC protects cells from lead-induced oxidative damage by boosting the PC-12 cells’ antioxidant defense mechanisms.
Starting Page 119
Ending Page 123
Page Count 5
File Format PDF
ISSN 00904341
Journal Archives of Environmental Contamination and Toxicology
Volume Number 49
Issue Number 1
e-ISSN 14320703
Language English
Publisher Springer-Verlag
Publisher Date 2005-06-20
Publisher Place New York
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Agriculture Ecology Forestry Environment Soil Science & Conservation Terrestrial Pollution
Content Type Text
Resource Type Article
Subject Pollution Health, Toxicology and Mutagenesis Medicine Toxicology
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