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  1. Naunyn-Schmiedeberg's Archives of Pharmacology
  2. Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389
  3. Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 11, November 2016
  4. Amarogentin ameliorates diabetic disorders in animal models
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Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 390
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 12, December 2016
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 11, November 2016
Phosphodiesterase 2: anti-adrenergic friend or hypertrophic foe in heart disease?
Response to Wagner et al.: phosphodiesterase-2—anti-adrenergic friend or hypertrophic foe in heart disease?
Combined oral contraceptive-induced hypertension is accompanied by endothelial dysfunction and upregulated intrarenal angiotensin II type 1 receptor gene expression
Captopril improves postresuscitation hemodynamics protective against pulmonary embolism by activating the ACE2/Ang-(1-7)/Mas axis
Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein
Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3′, 4′-pentamethoxyflavone to middle-aged male rats
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice
Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes
Amarogentin ameliorates diabetic disorders in animal models
Epigallocatechin-3-gallate inhibits angiotensin II-induced C-reactive protein generation through interfering with the AT1-ROS-ERK1/2 signaling pathway in hepatocytes
Rubus imperialis (Rosaceae) extract and pure compound niga-ichigoside F1: wound healing and anti-inflammatory effects
Beta-cyclodextrin enhanced gastroprotective effect of (−)-linalool, a monoterpene present in rosewood essential oil, in gastric lesion models
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 10, October 2016
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 9, September 2016
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 7, July 2016
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 389, Issue 6, June 2016
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 381
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 360
Naunyn-Schmiedeberg's Archives of Pharmacology : Volume 359

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Amarogentin ameliorates diabetic disorders in animal models

Content Provider SpringerLink
Author Niu, Ho Shan Chao, Pin Chun Ku, Po Ming Niu, Chiang Shan Lee, Kung Shing Cheng, Juei Tang
Copyright Year 2016
Abstract Amarogentin is a bitter-tasting secoiridoid glycoside isolated from an herb. Inhibition of aldose reductase by amarogentin has been documented as an antidiabetic action. However, the mechanisms of action of amarogentin in diabetic disorders remain unknown. The present study employed streptozotocin-induced type 1 diabetic (T1DM) rats to investigate the antihyperglycemic action of amarogentin. Changes in the protein expression of glucose transporter 4 (GLUT4) and phosphoenolpyruvate carboxykinase (PEPCK) in skeletal muscle and liver, respectively, were also detected by Western blotting. Additionally, a type 2 diabetes (T2DM) animal model induced using a fructose-rich diet was also applied to assess the effect of amarogentin on insulin resistance according to the homeostasis model assessment-insulin resistance (HOMA-IR). Amarogentin dose-dependently attenuated hyperglycemia in the T1DM rats lacking insulin. The action of amarogentin was further supported in rats administered the oral glucose tolerance test. Western blotting showed that amarogentin reversed the decreased GLUT4 level in skeletal muscle and reduced the elevated PEPCK expression in livers isolated from the T1DM rats. Moreover, amarogentin decreased the HOMA-IR and increased insulin sensitivity in the T2DM rats. These data show that amarogentin may ameliorate glucose homeostasis in diabetic rats, indicating its potential for future development as an antidiabetic drug.
Starting Page 1215
Ending Page 1223
Page Count 9
File Format PDF
ISSN 00281298
Journal Naunyn-Schmiedeberg's Archives of Pharmacology
Volume Number 389
Issue Number 11
e-ISSN 14321912
Language English
Publisher Springer Berlin Heidelberg
Publisher Date 2016-08-03
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Amarogentin Fructose-rich chow Insulin resistance Streptozotocin Insulin-independent action Rats Pharmacology/Toxicology Neurosciences
Content Type Text
Resource Type Article
Subject Medicine Pharmacology
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