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TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation
Content Provider | Scilit |
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Author | Lee, Soo Young Lee, Sang Yull Choi, Yongwon |
Copyright Year | 1997 |
Description | Through their interaction with the TNF receptor–associated factor (TRAF) family, members of the tumor necrosis factor receptor (TNFR) superfamily elicit a wide range of biological effects including differentiation, proliferation, activation, or cell death. We have identified and characterized a novel component of the receptor–TRAF signaling complex, designated TRIP (TRAF-interacting protein), which contains a RING finger motif and an extended coiled-coil domain. TRIP associates with the TNFR2 or CD30 signaling complex through its interaction with TRAF proteins. When associated, TRIP inhibits the TRAF2-mediated NF-κB activation that is required for cell activation and also for protection against apoptosis. Thus, TRIP acts as a receptor–proximal regulator that may influence signals responsible for cell activation/proliferation and cell death induced by members of the TNFR superfamily. |
Related Links | http://jem.rupress.org/content/jem/185/7/1275.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196258/pdf https://rupress.org/jem/article-pdf/185/7/1275/967537/5490.pdf |
Ending Page | 1286 |
Page Count | 12 |
Starting Page | 1275 |
DOI | 10.1084/jem.185.7.1275 |
Journal | The Journal of experimental medicine |
Issue Number | 7 |
Volume Number | 185 |
Language | English |
Publisher | Rockefeller University Press |
Publisher Date | 1997-04-07 |
Access Restriction | Open |
Subject Keyword | Cell Biology Protein Binding Proteins Binding Sites Amino Acid Sequence Nf Kappa B Tumor Necrosis Factor Receptor Signal Transduction Journal: The Journal of experimental medicine (Vol- 185, Issue- 7) |
Content Type | Text |
Resource Type | Article |