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Content Provider | Journal of Biological Chemistry (JBC) |
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Author | Suhre, Karsten Claverie, Jean-Michel |
Abstract | It has been shown (Cambillau, C., and Claverie, J. M. (2000) J. Biol. Chem. 275, 32383–32386) that a large difference between the proportions of charged versus polar (non-charged) amino acids (CvP-bias) was an adequate, if empirical, signature of the proteome of hyperthermophilic organisms (T growth >80 °C). Since that study, the number of available microbial genomes has more than doubled, raising the possibility that the simple CvP-bias rule might no longer hold. Taking advantage of the new sequence data, we re-analyzed the genomes of 9 fully sequenced thermophiles, 9 hyperthermophiles, and 53 mesothermophile microorganisms to identify the genomic correlates of hyperthermostability on a wider data set. Our new results confirm that the CvP-bias previously identified on a much smaller data set still holds. Moreover, we show that it is an optimal criterion, in the sense that it corresponds to the most discriminating factor between hyperthermophilic and mesothermophilic microorganisms in a principal component analysis. In parallel, we evaluated two other recently proposed correlates of hyperthermostability, the proteome average pI and the dinucleotide statistical index (Kawashima, T., Amano, N., Koike, H., Makino, S., Higuchi, S., Kawashima-Ohya, Y., Watanabe, K., Yamazaki, M., Kanehori, K., Kawamoto, T., Nunoshiba, T., Yamamoto, Y., Aramaki, H., Makino, K., and Suzuki, M. (2000) Proc. Natl. Acad. Sci.97, 14257–14262). We show that the CvP-bias is the sole criterion that is able to clearly discriminate hyperthermophile from mesothermophile microorganisms on a global genomic basis. |
Related Links | http://www.jbc.org/content/278/19/17198.abstract |
Ending Page | 17202 |
Starting Page | 17198 |
Page Count | 5 |
File Format | HTM / HTML PDF |
ISSN | 00219258 |
Journal | Journal of Biological Chemistry (JBC) |
Issue Number | 19 |
Volume Number | 278 |
DOI | 10.1074/jbc.M301327200 |
e-ISSN | 1083351X |
Language | English |
Publisher | American Society for Biochemistry and Molecular Biology |
Publisher Date | 2003-05-09 |
Access Restriction | Open |
Subject Keyword | Charged versus polar (CvP) Optimal growth temperature (OGT) Principal component analysis (PCA) Guanine + cytosine (G + C) GENOMICS PROTEOMICS AND BIOINFORMATICS |
Content Type | Text |
Resource Type | Article |
Subject | Molecular Biology Cell Biology Biochemistry |
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