NDLI: Polynomial-time controllability analysis of Boolean networks

Content Provider	IEEE Xplore Digital Library
Author	Kobayashi, K. Imura, J.-i. Hiraishi, K.
Copyright Year	2009
Description	Author affiliation: Tokyo Institute of Technology, 152-8552, Japan (Imura, J.-i.) \|\| Japan Advanced Institute of Science and Technology, Ishikawa 923-1292, Japan (Kobayashi, K.; Hiraishi, K.)
Abstract	This paper discusses the controllability problem of Boolean networks with inputs (control nodes) and outputs (controlled nodes). An algorithm for testing controllability is in general NP-hard, and the existing polynomial-time algorithm is limited to a class of tree-structure networks. In this paper, based on a sufficient condition for controllability, a polynomial-time algorithm is proposed. The proposed algorithm is applicable to a wider class of large-scale Boolean networks compared with the existing algorithm. The key idea in our approach is to use an adjacency matrix of a directed graph induced by a Boolean network, and Boolean operations are not focused. The effectiveness of the proposed approach is shown by an example of a biological network.
Starting Page	1694
Ending Page	1699
File Size	684744
Page Count	6
File Format	PDF
ISBN	9781424445233
ISSN	07431619
DOI	10.1109/ACC.2009.5160280
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-06-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	American Automatic Control Council(AACC)
Subject Keyword	Polynomials Controllability Biological system modeling Sufficient conditions Testing Large-scale systems Biological control systems Boolean functions Biology Tree graphs
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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