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Case report of an elderly woman with atypical imaging for primary central nervous system lymphoma who needed a brain biopsy for diagnosis.
Content Provider | Europe PMC |
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Author | Matsuzono, Kosuke Yagisawa, Tomoya Ohtani, Keisuke Ishishita, Yohei Yamaguchi, Takashi Mashiko, Takafumi Ozawa, Tadashi Koide, Reiji Tanaka, Ryota Kawai, Kensuke Fujimoto, Shigeru |
Copyright Year | 2021 |
Abstract | Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkinlymphoma, but its diagnosis is challenging in some cases. A brain biopsy is thegold standard for diagnosing PCNSL, but its invasiveness can be problematic.Thus, noninvasive imaging examinations have been developed for the pre-surgicaldiagnosis of PCNSL, including gadolinium-enhanced magnetic resonance imaging(MRI), 123I-N-isopropyl-p-iodoamphetamine single-photon emissioncomputed tomography (123I-IMP SPECT), and positron emissiontomography with 18F-fluorodeoxyglucose (18F-FDG PET).Here, we report the case of a 71-year-old woman with negative imaging findingsfor PCNSL, but who was diagnosed with PCNSL by a brain biopsy and histologicalanalysis. Her imaging results were negative for gadolinium-enhanced cranial MRI,with low uptake in 123I-IMP SPECT and hypometabolism in18F-FDG PET. However, a stereotactic brain biopsy from an abnormallesion revealed that many round cells had infiltrated into the brain. Moreover,many infiltrating cells were positive for cluster of differentiation (CD)20 andCD79a, and proliferation marker protein Ki-67-positive cells accounted fornearly 80% of all cells. Based on these results, our final pathologicaldiagnosis was PCNSL. The present case highlights the possibility of a PCNSLdiagnosis even when all imaging-related examinations display negativeresults. |
ISSN | 03000605 |
Volume Number | 49 |
PubMed Central reference number | PMC8414941 |
Issue Number | 8 |
PubMed reference number | 34461767 |
Journal | The Journal of International Medical Research [J. Int. Med. Res] |
e-ISSN | 14732300 |
DOI | 10.1177/03000605211035197 |
Publisher | SAGE Publications |
Publisher Date | 2021-08-01 |
Publisher Place | Sage UK: London, England |
Access Restriction | Open |
Rights License | Creative Commons Non Commercial CC BY-NC: This article is distributedunder the terms of the Creative Commons Attribution-NonCommercial 4.0License (https://creativecommons.org/licenses/by-nc/4.0/) whichpermits non-commercial use, reproduction and distribution of the workwithout further permission provided the original work is attributed asspecified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). © The Author(s) 2021 |
Subject Keyword | Primary central nervous system lymphoma brain biopsy magnetic resonance imaging single-photon emission computed tomography positron-emission tomography with 18F-fluorodeoxyglucose diagnosis |
Content Type | Text |
Resource Type | Article |
Subject | Biochemistry Cell Biology Biochemistry (medical) |