NDLI: Synthesis, Characterization and Antibacterial Activity of N-(N-Acetic Acid-yl-Phthalimide-5-yl) Maleamic Acid Dihydrate

Content Provider	SpringerLink
Author	Li, Jian
Copyright Year	2009
Abstract	The compound N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid (C$_{14}$H$_{10}$N$_{2}$O$_{7}$, M $_{r}$ = 318) was synthesized and its structure was characterized by elemental analysis, $^{1}$H NMR and IR spectra. The single crystal of the title compound (C$_{14}$H$_{14}$N$_{2}$O$_{9}$, M $_{r}$ = 354.27) was cultured and its structure was determined by single crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 14.3859(19), b = 12.5835(18), c = 8.6934(15) Å, β = 102.824(2)°, V = 1534.5(4) Å$^{3}$, Z = 4, D $_{c}$ = 1.534 g cm$^{−3}$, μ(Mo Kα) = 0.131 mm$^{−1}$, F(000) = 736. The final refinement gave R = 0.0652, wR(F $^{2}$) = 0.1239 for 2,703 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals that the asymmetric unit of the title compound contains one N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid molecule and two water molecules. One of the two water molecules is disordered. The phthalimide group is essentially planar. The crystal structure of the title compound is stabilized by N–H…O and O–H…O hydrogen bonds interactions. The compound N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid possesses moderate antibacterial activity.The compound N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid (C$_{14}$H$_{10}$N$_{2}$O$_{7}$, M $_{r}$ = 318) was synthesized and its structure was characterized by elemental analysis, $^{1}$H NMR and IR spectra. The single crystal of the title compound (C$_{14}$H$_{14}$N$_{2}$O$_{9}$, M $_{r}$ = 354.27) was cultured and its structure was determined by single crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 14.3859(19), b = 12.5835(18), c = 8.6934(15) Å, β = 102.824(2)°, V = 1534.5(4) Å$^{3}$, Z = 4, D $_{c}$ = 1.534 g/cm$^{3}$, μ(Mo Kα) = 0.131 mm$^{−1}$, F(000) = 736. The final refinement gave R = 0.0652, wR(F $^{2}$) = 0.1239 for 2,703 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals that the asymmetric unit of the title compound contains one N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid molecule and two water molecules. One of the two water molecules is disordered. The phthalimide group is essentially planar. The crystal structure of the title compound is stabilized by N–H…O and O–H…O hydrogen bonds interactions. The compound N-(N-acetic acid-yl-phthalimide-5-yl) maleamic acid possesses moderate antibacterial activity.
Starting Page	428
Ending Page	431
Page Count	4
File Format	PDF
ISSN	10741542
Journal	Journal of Chemical Crystallography
Volume Number	40
Issue Number	5
e-ISSN	15728854
Language	English
Publisher	Springer US
Publisher Date	2009-12-19
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	N-(N-acetic acid-yl-phthalimide-5-yl)maleamic acid dihydrate Synthesis Crystal structure Characterization Antibacterial activity Inorganic Chemistry Physical Chemistry Crystallography Organometallic Chemistry
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Chemistry

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