NDLI: Conventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation

Content Provider	SpringerLink
Author	Sondhi, Sham M. Singh, Jaiveer Roy, Partha Agrawal, S. K. Saxena, A. K.
Copyright Year	2010
Abstract	A number of imidazole derivatives 3a–f and 4a–f have been synthesized by the condensation of 3-methylthiophen-2-carboxaldehyde 1a, 5-methylthiophen-2-carboxaldehyde 1b, N-methylpyrrol-2-carboxaldehyde 1c, 1-naphthaldehyde 1d, 2-naphthaldehyde 1e, and 2-hydroxy-1-naphthaldehyde 1f with 1,2-diaminoanthraquinone 2a and 2,3-diaminophenazine 2b, respectively. Condensation of 2-guanidinobenzimidazole with functionalized aldehydes 1a–f leads to the formation of guanidine derivatives 5a–f. Both imidazole (3a–f, 4a–f) and guanidine derivatives (5a–f) were synthesized in good yields using conventional heating and microwave irradiation techniques. Structures assigned to compounds 3a–f, 4a–f and 5a–f are supported by correct spectral and analytic data. On screening for anti-inflammatory and anticancer activities, compounds 3e, 4a and 5a exhibited good anti-inflammatory and compounds 3d, 3f, 4d and 4f showed very good anticancer activity.
Starting Page	887
Ending Page	897
Page Count	11
File Format	PDF
ISSN	10542523
Journal	Medicinal Chemistry Research
Volume Number	20
Issue Number	7
e-ISSN	15548120
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-09-02
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Imidazole Guanidine Microwave irradiation Anti-inflammatory Anticancer Cell Biology Pharmacology/Toxicology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Pharmacology, Toxicology and Pharmaceutics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Libarray of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives

Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities

Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives

Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

Synthesis, anti-inflammatory evaluation, and docking studies of some new thiazole derivatives

Microwave-assisted synthesis of triazolothiadiazole analogs as anticancer agents

Microwave-assisted synthesis of novel 1,2,3-triazole derivatives and their antimicrobial activity

New N-arylamino biquinoline derivatives: microwave-assisted synthesis and their antimicrobial activities

Synthesis and biological evaluation of anti-inflammatory activity of 1,3 diphenyl propenone derivatives

Conventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation

Similar Documents

Microwave-assisted synthesis and evaluation of anti-inflammatory activity of new series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives

Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities

Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives

Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

Synthesis, anti-inflammatory evaluation, and docking studies of some new thiazole derivatives

Microwave-assisted synthesis of triazolothiadiazole analogs as anticancer agents

Microwave-assisted synthesis of novel 1,2,3-triazole derivatives and their antimicrobial activity

New N-arylamino biquinoline derivatives: microwave-assisted synthesis and their antimicrobial activities

Synthesis and biological evaluation of anti-inflammatory activity of 1,3 diphenyl propenone derivatives

Conventional and microwave-assisted synthesis of imidazole and guanidine derivatives and their biological evaluation