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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Stummvoll, Georg H. Glass, Deborah D. Huter, Eva N. Shevach, Ethan M. DiPaolo, Richard J. |
Description | Country affiliation: United States Author Affiliation: Huter EN ( Laboratory of Immunology, Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. eshevach@niaid.nih.gov) |
Abstract | CD4(+) T cells from the TCR transgenic TxA23 mouse recognize a peptide from the H/K-ATPase alpha-chain. When TxA23 CD4(+) thymocytes are differentiated into Th1, Th2, and Th17 lines, all three subpopulations induced autoimmune gastritis (AIG) upon transfer into nu/nu recipients. The induction of AIG by naive T cells or by Th1 or Th2 cell lines could be prevented by the cotransfer of polyclonal Foxp3(+) T regulatory cells (nTreg), whereas Th17-induced AIG was resistant to suppression. We compared the capacity of different types of Treg to suppress Th17-mediated AIG. Cotransfer of either nTreg or polyclonal TGFbeta-induced Treg (iTreg) did not prevent AIG, while cotransfer of TGFbeta-induced Ag-specific TxA23 iTreg completely prevented the development of disease. Ag-specific iTreg were able to suppress Th17-mediated disease when injected 6 days after the Th17 effectors. The implications of these results for the use of Treg for the cellular biotherapy of autoimmune disease are discussed. |
ISSN | 00221767 |
e-ISSN | 15506606 |
Journal | The Journal of Immunology |
Issue Number | 12 |
Volume Number | 181 |
Language | English |
Publisher | The American Association of Immunologists |
Publisher Date | 2008-12-15 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Autoimmune Diseases Prevention & Control Epitopes, T-lymphocyte Immunology Gastritis Interleukin-17 Physiology T-lymphocytes, Regulatory Transforming Growth Factor Beta Adoptive Transfer Animals Cells, Cultured Biosynthesis Mice Mice, Inbred Balb C Mice, Nude Mice, Transgenic Metabolism Transplantation Research Support, N.i.h., Intramural Discipline Immunology |
Content Type | Text |
Resource Type | Article |
Subject | Immunology and Allergy Immunology |
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