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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Li, Qian Wang, Wei Ge, Qing Yin, Yanhui Zhang, Yu Wu, Hounan Zhang, Jun |
Description | Country affiliation: China Author Affiliation: Wang W ( Department of Immunology, Peking University Health Science Center, Beijing, China.) |
Abstract | Hemokinin 1 (HK-1) is a substance P-like tachykinin peptide predominantly expressed in non-neuronal tissues. In addition to a prominent function in lymphoid development, recent studies indicate a potential role for HK-1 in immunoregulation. The current study was focused on its action on mature B cells. Despite the negligible effect on its own, HK-1 exhibited a profound influence on B cell activation elicited by several classical signals, including LPS stimulation, BCR cross-linking, and CD40 ligation. Cells therefore showed enhanced proliferation, survival, and CD80/86 expression, and produced more IgM with a higher frequency of Ab-forming cells. Biochemical analysis revealed that HK-1 alone was sufficient to induce the activation of MAPKs and the expression of Blimp-1 and Xbp-1 in B cells. Nevertheless, costimulation with a known B cell activator resulted in much enhanced phosphorylation of MAPKs and transcriptional activation of Blimp-1 and Xbp-1. Overall, these data support that HK-1 provides an important costimulatory signal for B cell activation, possibly through synergistic activation of the MAPK pathway and induction of transcription factors critical for plasmacytic differentiation. |
ISSN | 00221767 |
e-ISSN | 15506606 |
Journal | The Journal of Immunology |
Issue Number | 7 |
Volume Number | 184 |
Language | English |
Publisher | The American Association of Immunologists |
Publisher Date | 2010-04-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Antibody Formation Immunology B-lymphocytes Extracellular Signal-regulated Map Kinases Lymphocyte Activation Signal Transduction Tachykinins Animals Cytology Blotting, Western Cell Differentiation Cell Proliferation Cell Separation Cell Survival Dna-binding Proteins Biosynthesis Enzyme-linked Immunosorbent Assay Flow Cytometry Gene Expression Gene Expression Regulation Immunoglobulin M Mice Mice, Inbred C3h Mice, Inbred C57bl Reverse Transcriptase Polymerase Chain Reaction Transcription Factors Research Support, Non-u.s. Gov't Discipline Immunology |
Content Type | Text |
Resource Type | Article |
Subject | Immunology and Allergy Immunology |
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