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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Succurro, Elena Marini, Maria Adelaide Arturi, Franco Hribal, Marta Letizia Andreozzi, Francesco Sesti, Giorgio Perticone, Maria Perticone, Francesco Fiorentino, Teresa Vanessa Sciacqua, Angela |
Description | Author Affiliation: Fiorentino TV ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Marini MA ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Andreozzi F ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Arturi F ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Succurro E ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Perticone M ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Sciacqua A ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Hribal ML ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Perticone F ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy); Sesti G ( Department of Medical and Surgical Sciences (T.V.F., F.An., F.Ar., E.S., M.P., A.S., M.L.H., F.P., G.S.), University Magna Graecia of Catanzaro, Catanzaro, 88100 Italy) |
Abstract | CONTEXT: Subjects with normal glucose tolerance (NGT) but 1-h postload glucose ≥ 155 mg/dL (NGT-1h-high) exhibit an intermediate cardiometabolic risk profile between individuals with NGT and impaired glucose tolerance (IGT). OBJECTIVE: This study aimed to evaluate whether NGT-1h-high subjects have different cardiometabolic characteristics and an increased risk of type 2 diabetes compared with individuals with isolated impaired fasting glucose (IFG). SETTING, DESIGN, AND PATIENTS: A cross-sectional analysis was performed on 595 nondiabetic subjects who underwent an oral glucose tolerance test and an euglycemic hyperinsulinemic clamp in an ambulatory care setting. In addition, a longitudinal analysis was performed on 392 individuals, who were reexamined after a followup of 5.2 ± 0.9 y. MAIN OUTCOME MEASURES: Insulin sensitivity, beta-cell function, and risk of developing diabetes were measured. RESULTS: Subjects with NGT-1h-high have a significant reduction of peripheral insulin sensitivity and beta-cell function, assessed by the disposition index, compared with either 1-h postload glucose < 155 mg/dL (NGT-1h-low) or IFG individuals, but not compared with IGT. Among the 392 subjects studied in the longitudinal analysis the incidence rate of type 2 diabetes over the follow-up period was 2.9, 16.7, 12.5, and 31.4% for subjects with NGT-1h-low, NGT-1h-high, IFG, and IGT, respectively. In a Cox proportional hazard regression analysis the risk of developing diabetes for NGT-1h-high subjects was 4.02 (95% confidence interval [CI] 1.06-15.26); an even higher risk (6.67; 95% CI, 2.09-21.24) was observed in subjects with IGT, but not in the isolated IFG group (1.91; 95% CI, 0.44-8.29). CONCLUSIONS: NGT-1h-high subjects exhibit a higher risk of developing diabetes than those with IFG or NGT-1h-low, likely due to decreased insulin sensitivity and beta-cell function. |
ISSN | 0021972X |
e-ISSN | 19457197 |
Journal | The Journal of Clinical Endocrinology & Metabolism |
Issue Number | 10 |
Volume Number | 100 |
Language | English |
Publisher | Oxford University Press |
Publisher Date | 2015-10-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Blood Glucose Diabetes Mellitus, Type 2 Diagnosis Fasting Blood Hyperglycemia Insulin Resistance Physiology Cross-sectional Studies Glucose Clamp Technique Glucose Tolerance Test Discipline Endocrinology Discipline Metabolism |
Content Type | Text |
Resource Type | Article |
Subject | Biochemistry (medical) Biochemistry Clinical Biochemistry Endocrinology Endocrinology, Diabetes and Metabolism |
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