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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Alhadlaq, Hisham A. Khan, M. A. Majeed Alrokayan, Salman A. Ahamed, Maqusood Akhtar, Mohd Javed |
Description | Author Affiliation: Akhtar MJ ( King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: mohd.j.akhtar@gmail.com.); Ahamed M ( King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.); Alhadlaq HA ( King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia); Khan MA ( King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.); Alrokayan SA ( Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.) |
Abstract | Recently, cerium oxide nanoparticles (CeO2 NPs) has been reported for multi-enzyme mimetic activities like that of superoxide dismutase and catalase. Here, we report glutathione (GSH) replenishing response by CeO2 NPs in human breast (MCF-7) and fibrosarcoma (HT-1080) cells. CeO2 NPs were found to be mostly cuboidal in shape with average diameter of 25 nm. Effects on cell viability, reactive oxygen species (ROS) generation, and mitochondrial outer membrane potential (MOMP) suggested CeO2 NPs to be reasonably non-cytotoxic. Data on membrane damage and lipid peroxidation correlated well with the cell viability results suggesting NPs of CeO2 to be biocompatible. Interestingly, CeO2 NPs significantly increased intracellular GSH in cells challenged with oxidants. Replenishment of depleted GSH in oxidatively challenged cells was comparable with the GSH restoring potential of known antioxidant N-acetyl cysteine (NAC), a precursor of GSH. Like NAC, CeO2 NPs significantly replenished depleted GSH in both cell types challenged with hydrogen peroxide (H2O2) and zinc oxide (ZnO) NPs. Moreover, CeO2 NPs treated cells were significantly protected from cytotoxicity caused by H2O2 and ZnO NPs. Our findings, therefore, suggest CeO2 NPs as a potential antioxidant rather than a toxic material. |
ISSN | 00219797 |
Volume Number | 453 |
e-ISSN | 10957103 |
Journal | Journal of Colloid and Interface Science |
Language | English |
Publisher | Elsevier |
Publisher Date | 2015-09-01 |
Publisher Place | United States |
Access Restriction | Subscribed |
Subject Keyword | Antioxidants Pharmacology Cerium Glutathione Metabolism Nanoparticles Chemistry Breast Neoplasms Cell Line, Tumor Cell Survival Drug Effects Female Fibrosarcoma Humans Ultrastructure Reactive Oxygen Species Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Cells Eukaryota Neoplasms Inorganic Chemicals Amino Acids, Peptides, and Proteins Chemical Actions and Uses Cell Physiological Phenomena Technology, Industry, and Agriculture |
Subject | Surfaces, Coatings and Films Biomaterials Colloid and Surface Chemistry Electronic, Optical and Magnetic Materials |
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