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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Wisniewski, H. G. Lee, T. H. Vilcek, J. |
Description | Author Affiliation: Lee TH ( Department of Microbiology, New York University Medical Center, New York 10016.) |
Abstract | TSG-6 cDNA was isolated by differential screening of a lambda cDNA library prepared from tumor necrosis factor (TNF)-treated human diploid FS-4 fibroblasts. We show that TSG-6 mRNA was not detectable in untreated cells, but became readily induced by TNF in normal human fibroblast lines and in peripheral blood mononuclear cells. In contrast, TSG-6 mRNA was undetectable in either control or TNF-treated human vascular endothelial cells and a variety of tumor-derived or virus-transformed cell lines. The sequence of full-length TSG-6 cDNA revealed one major open reading frame predicting a polypeptide of 277 amino acids, including a typical cleavable signal peptide. The NH2- terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44. The most extensive sequence homology exists between the predicted TSG-6 protein and CD44. Western blot analysis with an antiserum raised against a TSG-6 fusion protein detected a 39- kD glycoprotein in the supernatants of TNF-treated FS-4 cells and of cells transfected with TSG-6 cDNA. Binding of the TSG-6 protein to hyaluronate was demonstrated by coprecipitation. Our data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. |
ISSN | 00219525 |
e-ISSN | 15408140 |
Journal | The Journal of Cell Biology |
Issue Number | 2 |
Volume Number | 116 |
Language | English |
Publisher | Rockefeller University Press (United States) |
Publisher Date | 1992-01-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Cell Adhesion Molecules Metabolism Hyaluronic Acid Tumor Necrosis Factor-alpha Pharmacology Amino Acid Sequence Chemistry Immunology Gene Expression Glycoproteins Infant, Newborn Molecular Sequence Data Molecular Weight RNA, Messenger Genetics Receptors, Lymphocyte Homing Sequence Alignment Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
Content Type | Text |
Resource Type | Article |
Subject | Cell Biology Medicine |
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