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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Vercelli, D. Ishizaka, K. Helm, B. Glovsky, M. M. Gould, H. Geha, R. Kebo, D. Ishizaka, T. |
Description | Author Affiliation: Helm B ( Division of Molecular Biology and Biotechnology/Biochemistry, Sheffield University, England.); |
Abstract | The recombinant peptide corresponding to residues 301-376 at the junction of constant regions 2 and 3 of the human IgE epsilon chain blocked the in vivo passive sensitization of human skin mast cells and in vitro sensitization of human basophil granulocytes with human IgE antibodies. An injection of the recombinant peptide or E myeloma protein into normal skin sites 1 hr before sensitization with an allergic serum blocked passive sensitization. In this system, approximately 10-fold higher molar concentration of the recombinant peptide than E myeloma protein was required for 50% inhibition of Prausnitz-Küstner reactions. When the mononuclear cells of two normal individuals were preincubated with the recombinant peptide or E myeloma protein for 15 min before passive sensitization with the same allergic serum and the cells were challenged with an optimal concentration of an antigen, approximately 11- to 13-fold higher concentration of the recombinant peptide than E myeloma protein was required for 50% inhibition of antigen-induced histamine release. Further studies with several recombinant peptides indicated that amino acid resides 363-376 in the Fc epsilon-chain fragment are not essential for binding of the peptide to Fc epsilon-chain receptor I. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 23 |
Volume Number | 86 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 1989-01-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Basophils Immunology Immunization, Passive Immunoglobulin E Immunoglobulin Heavy Chains Immunoglobulin Epsilon-Chains Mast Cells Cloning, Molecular DNA Genetics Escherichia Coli Molecular Sequence Data Oligodeoxyribonucleotides Recombinant Proteins Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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