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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Meister, Stephan Kafatos, Fotis C. Zheng, Xue-li Clayton, John Randall Kanzok, Stefan M. Christophides, George K. White, Kevin P. Zheng, Liangbiao Li, Tong-ruei Hoa, Ngo T. Luna, Coralia |
Description | Author Affiliation: Meister S ( European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.); |
Abstract | We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-kappaB-like transcription factor orthologous to Drosophila Relish. Through alternative splicing, REL2 produces a full-length (REL2-F) and a shorter (REL2-S) protein isoform lacking the inhibitory ankyrin repeats and death domain. RNA interference experiments show that, in contrast to Drosophila Relish, which responds solely to Gram-negative bacteria, the Anopheles REL2-F and REL2-S isoforms are involved in defense against the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli bacteria, respectively. REL2-F also regulates the intensity of mosquito infection with the malaria parasite, Plasmodium berghei. The adaptor IMD shares the same activities as REL2-F. Microarray analysis identified 10 additional genes regulated by REL2, including CEC3, GAM1, and LRIM1. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 32 |
Volume Number | 102 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 2005-08-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Anopheles Gambiae Immunology Gene Expression Regulation Insect Proteins Plasmodium Berghei Signal Transduction Transcription Factors Alternative Splicing Genetics Animals Microbiology Parasitology Escherichia Coli Genome Components Metabolism Luciferases Microarray Analysis Reverse Transcriptase Polymerase Chain Reaction Staphylococcus Aureus Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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