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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Ishihara, Akane Macneil, Douglas J. Miyamoto, Yasuhisa Takahashi, Kazuhiko Kotani, Hidehito Yoshimoto, Ryo Tokita, Shigeru Shimamura, Ken Chen, Airu S. Chen, Howard Y. Kanatani, Akio |
Description | Author Affiliation: Yoshimoto R ( Tsukuba Research Institute, Banyu Pharmaceutical Company, Ltd., Tsukuba, Ibaraki 300-2611, Japan.); |
Abstract | Histamine H3 receptors (H3Rs) are located on the presynaptic membranes and cell soma of histamine neurons, where they negatively regulate the synthesis and release of histamine. In addition, H3Rs are also located on nonhistaminergic neurons, acting as heteroreceptors to regulate the releases of other amines such as dopamine, serotonin, and norepinephrine. The present study investigated the effects of H3R ligands on appetite and body-weight regulation by using WT and H3R-deficient mice (H3RKO), because brain histamine plays a pivotal role in energy homeostasis. The results showed that thioperamide, an H3R inverse agonist, increases, whereas imetit, an H3R agonist, decreases appetite and body weight in diet-induced obese (DiO) WT mice. Moreover, in DiO WT mice, but not in DiO H3RKO mice, imetit reduced fat mass, plasma concentrations of leptin and insulin, and hepatic triglyceride content. The anorexigenic effects of imetit were associated with a reduction in histamine release, but a comparable reduction in histamine release with alpha-fluoromethylhistidine, an inhibitor of histamine synthesis, increased appetite. Moreover, the anorexigenic effects of imetit were independent of the melanocortin system, because imetit comparably reduced appetite in melanocortin 3 and 4 receptor-deficient mice. The results provide roles of H3Rs in energy homeostasis and suggest a therapeutic potential for H3R agonists in the treatment of obesity and diabetes mellitus. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 37 |
Volume Number | 103 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 2006-09-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Appetite Drug Effects Body Weight Diabetes Mellitus Metabolism Histamine Agonists Pharmacology Imidazoles Therapeutic Use Obesity Thiourea Analogs & Derivatives Animals Drug Therapy Insulin Blood Leptin Mice Mice, Knockout Piperidines Receptors, Histamine H3 Genetics Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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