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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Sheff, David Okazaki, Seiji Wakatsuki, Soichi Uchida, Yasunori Inoue, Takao Taguchi, Tomohiko Koike, Masato Mukai, Kojiro Lencer, Wayne I. Nishikawa, Kiyotaka Hasegawa, Junya Kato, Ryuichi Nakagawa, Takatoshi Miyoshi, Eiji Kuwahara, Ryusuke Misaki, Ryo Chinnapen, Daniel Arai, Hiroyuki Iemura, Shun-ichiro Natsume, Tohru Taniguchi, Naoyuki Uchiyama, Yasuo |
Description | Author Affiliation: Uchida Y ( Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.); |
Abstract | Phosphatidylserine (PS) is a relatively minor constituent of biological membranes. Despite its low abundance, PS in the plasma membrane (PM) plays key roles in various phenomena such as the coagulation cascade, clearance of apoptotic cells, and recruitment of signaling molecules. PS also localizes in endocytic organelles, but how this relates to its cellular functions remains unknown. Here we report that PS is essential for retrograde membrane traffic at recycling endosomes (REs). PS was most concentrated in REs among intracellular organelles, and evectin-2 (evt-2), a protein of previously unknown function, was targeted to REs by the binding of its pleckstrin homology (PH) domain to PS. X-ray analysis supported the specificity of the binding of PS to the PH domain. Depletion of evt-2 or masking of intracellular PS suppressed membrane traffic from REs to the Golgi. These findings uncover the molecular basis that controls the RE-to-Golgi transport and identify a unique PH domain that specifically recognizes PS but not polyphosphoinositides. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 38 |
Volume Number | 108 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 2011-09-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Endosomes Metabolism Intracellular Membranes Membrane Proteins Phosphatidylserines Animals COS Cells Cercopithecus Aethiops Crystallography, X-Ray Ultrastructure Golgi Apparatus Green Fluorescent Proteins Genetics HeLa Cells Chemistry Microscopy, Fluorescence Microscopy, Immunoelectron Models, Biological Protein Binding Protein Structure, Tertiary Protein Transport RNA Interference Vero Cells Research Support, Non-U.S. Gov't Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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