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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Epstein, David Sculpher, Mark J. Bojke, Laura |
Description | Author Affiliation: Epstein D ( Centre for Health Economics, University of York, Heslington, York YO1 5DD.); |
Abstract | Objective To describe the long term costs, health benefits, and cost effectiveness of laparoscopic surgery compared with those of continued medical management for patients with gastro-oesophageal reflux disease (GORD). Design We estimated resource use and costs for the first year on the basis of data from the REFLUX trial. A Markov model was used to extrapolate cost and health benefit over a lifetime using data collected in the REFLUX trial and other sources. Participants The model compared laparoscopic surgery and continued proton pump inhibitors in male patients aged 45 and stable on GORD medication. Intervention Laparoscopic surgery versus continued medical management. Main outcome measures We estimated quality adjusted life years and GORD related costs to the health service over a lifetime. Sensitivity analyses considered other plausible scenarios, in particular size and duration of treatment effect and the GORD symptoms of patients in whom surgery is unsuccessful. Main results The base case model indicated that surgery is likely to be considered cost effective on average with an incremental cost effectiveness ratio of £2648 (€3110; US\$4385) per quality adjusted life year and that the probability that surgery is cost effective is 0.94 at a threshold incremental cost effectiveness ratio of £20 000. The results were sensitive to some assumptions within the extrapolation modelling. Conclusion Surgery seems to be more cost effective on average than medical management in many of the scenarios examined in this study. Surgery might not be cost effective if the treatment effect does not persist over the long term, if patients who return to medical management have poor health related quality of life, or if proton pump inhibitors were cheaper. Further follow-up of patients from the REFLUX trial may be valuable. Trial registration ISRCTN15517081. |
ISSN | 09598138 |
e-ISSN | 17561833 |
Journal | BMJ (British Medical Journal) |
Volume Number | 339 |
Language | English |
Publisher | British Medical Journal Publishing Group |
Publisher Date | 2009-08-01 |
Publisher Place | Great Britain (UK) |
Access Restriction | Open |
Subject Keyword | Fundoplication Gastroesophageal Reflux Laparoscopy Proton Pump Inhibitors Age Distribution Cost-Benefit Analysis Drug Therapy Surgery Health Resources Utilization Markov Chains Therapeutic Use Quality Of Life Quality-Adjusted Life Years Comparative Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Medicine |
Content Type | Text |
Resource Type | Article |
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