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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Pritchard, D. M. Berry, D. Przemeck, S. M. C. Campbell, F. Edwards, S. W. Varro, A. |
Description | Author Affiliation: Pritchard DM ( Division of Gastroenterology, School of Clinical Sciences, Univ. of Liverpool, The Henry Wellcome Laboratory, Nuffield Bldg., Crown St., Liverpool, L69 3GA UK. mark.pritchard@liv.ac.uk) |
Abstract | Elevated serum concentrations of the hormone gastrin are associated with the development of gastric carcinoid tumors, but the mechanisms of tumor development are not fully understood. We hypothesized that the antiapoptotic effects of gastrin may be implicated and have therefore investigated the role of antiapoptotic members of the bcl-2 family of proteins. AGS-G(R) human gastric carcinoma cells stably transfected with the CCK-2 receptor were used to assess changes in the expression of bcl-2 family members following gastrin treatment and the function of mcl-1 during apoptosis was investigated by use of small-interfering RNA (siRNA). Treatment of AGS-G(R) cells with 10 nM gastrin for 6 h caused maximally increased mcl-1 protein abundance. Gastrin-induced mcl-1 expression was inhibited by the transcription inhibitor actinomycin D and by the protein synthesis inhibitor cycloheximide. Downstream signaling of mcl-1 expression occurred via the CCK-2 receptor, protein kinase C, and MAP kinase pathways, but not via PI 3-kinase. Transfection with mcl-1 siRNA significantly suppressed mcl-1 protein expression and abolished the antiapoptotic effects of gastrin on serum starvation-induced apoptosis. Mcl-1 protein expression was also specifically increased in the type I enterochromaffin-like cell carcinoid tumors of 10 patients with autoimmune atrophic gastritis and hypergastrinemia. Gastrin therefore signals via the CCK-2 receptor, protein kinase C, and MAP kinase to induce expression of antiapoptotic mcl-1 in AGS-G(R) cells, and mcl-1 expression is also increased in human hypergastrinemia-associated type I gastric carcinoid tumors. Gastrin-induced mcl-1 expression may therefore be an important mechanism contributing toward type I gastric carcinoid development. |
File Format | HTM / HTML |
ISSN | 01931857 |
e-ISSN | 15221547 |
DOI | 10.1152/ajpgi.00015.2008 |
Journal | AJP: Gastrointestinal and Liver Physiology |
Issue Number | 4 |
Volume Number | 295 |
Language | English |
Publisher | American Physiological Society |
Publisher Date | 2008-10-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Discipline Physiology Discipline Gastroenterology Carcinoid Tumor Metabolism Gastrins Pharmacology Proto-oncogene Proteins C-bcl-2 Biosynthesis Receptor, Cholecystokinin B Stomach Neoplasms Blotting, Western Cell Line, Tumor Immunohistochemistry Myeloid Cell Leukemia Sequence 1 Protein Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject | Gastroenterology Physiology (medical) Physiology Hepatology |
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