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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Togashi, Yuko Miyamoto, Yohei |
Description | Country affiliation: Japan Author Affiliation: Togashi Y ( Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan.) |
Abstract | Cystatin C, a cysteine protease inhibitor, is a novel biomarker of renal damage. In the present study, we examined the usefulness of urinary cystatin C for the detection of diabetic nephropathy in Zucker diabetic fatty (ZDF) rats compared to other biomarkers (ß2-microglobulin, calbindin, clusterin, epidermal growth factor (EGF), alpha-glutathione S-transferase (GST- ), mu-glutathione S-transferase (GST-µ), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin, tissue inhibitor of metalloprotease-1 (TIMP-1), and vascular endothelial growth factor (VEGF). Urinary levels of cystatin C were increased in ZDF rats where renal damage was not histopathologically observed, and then further increased with the progression of renal damage, demonstrating the usefulness of early detection and accurate assessment of diabetic nephropathy. Urinary ß2-microglobulin, clusterin, GST-µ, KIM-1, and osteopontin had the potency to detect renal damage in ZDF rats as well as cystatin C. We also investigated immunohistochemical localization of cystatin C in the kidney according to progressive renal damage. Cystatin C expression was mainly observed in the proximal renal tubule in ZDF rats, and hardly changed with progression of nephropathy. When renal damage was remarkable, cystatin C expression was also observed in the tubular lumen of the cortex and medulla, which was considered to be characteristic of renal damage in diabetic nephropathy. In conclusion, urinary cystatin C, ß2-microglobulin, clusterin, GST-µ, KIM-1, and osteopontin could be useful biomarkers of diabetic nephropathy in ZDF rats. Immunohistochemical cystatin C expression in the proximal renal tubule was hardly changed by the progression of diabetic nephropathy, but it was newly observed in the tubular lumen when renal damage was remarkable in ZDF rats. |
File Format | HTM / HTML |
ISSN | 09402993 |
Issue Number | 5 |
Volume Number | 65 |
e-ISSN | 16181433 |
Journal | Experimental and Toxicologic Pathology |
Language | English |
Publisher | Elsevier |
Publisher Date | 2013-07-01 |
Publisher Place | Germany |
Access Restriction | Subscribed |
Subject Keyword | Discipline Toxicology Discipline Pathology Cystatin C Urine Diabetes Mellitus, Experimental Diabetic Nephropathies Kidney Metabolism Obesity Animals Biological Markers Blood Complications Pathology Immunohistochemistry Kidney Function Tests Male Pancreas Rats Rats, Zucker Journal Article |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Digestive System Urogenital System Eukaryota Male Urogenital Diseases Nutritional and Metabolic Diseases Amino Acids, Peptides, and Proteins Diagnosis |
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