NDLI: Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration.

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Year: 2008 Volume: 5 Issue: Supplementary 2

Year: 2008 Volume: 5 Issue: 1

Year: 2008 Volume: 5 Issue: Supplementary 1

Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smeets, Ralf Ulrich, Dietmar Unglaub, Frank Wöltje, Michael Pallua, Norbert
Description	Country affiliation: Germany Author Affiliation: Smeets R ( Interdisciplinary Centre of Clinical Research BioMAT, University Hospital Aachen, D-52074 Aachen, Germany. rasmeets@ukaachen.de)
Abstract	Oxidised regenerated cellulose/collagen matrix (ORC/collagen matrix) modifies wound microenvironments by binding and inactivating excess levels of proteases such as elastase, plasmin and gelatinases in wound exudates. To compare levels of the gelatinases matrix metalloproteinase 2 (MMP-2), elastase and plasmin in wound exudates collected from chronic venous insufficiency patients with venous leg ulcers treated with either an ORC/collagen matrix or a standard control therapy. During a 12-week treatment period, wound exudate samples were obtained from a control group of 10 patients treated with a hydrocolloid dressing and a treatment group of 17 patients treated with a combination of ORC/collagen matrix and hydrocolloid dressing. On admission and days 5, 14 and every subsequent 14th day, ulcers were photographed to determine healing rate and changes in ulcer appearance, and MMP-2 concentration and the gelatinase, elastase and plasmin activities were analysed from wound exudates. The patients treated with ORC/collagen matrix showed a significant decrease in elastase, plasmin and gelastinase activity as compared with the control group, with no significant difference in the MMP-2 concentrations between the two groups. The results show a significant and immediate reduction in protease activity in wound exudates from venous leg ulcers treated with ORC/collagen.
File Format	HTM / HTML
ISSN	17424801
Issue Number	2
Volume Number	5
e-ISSN	1742481X
Journal	International Wound Journal
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Traumatology Cellulose, Oxidized Collagen Exudates And Transudates Enzymology Hemostatics Peptide Hydrolases Metabolism Varicose Ulcer Aged Bandages Chronic Disease Female Humans Male Middle Aged Treatment Outcome Therapy Wound Healing Physiology Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Fluids and Secretions Eukaryota Cardiovascular Diseases Pathological Conditions, Signs and Symptoms Macromolecular Substances Enzymes and Coenzymes Chemical Actions and Uses Diagnosis Equipment and Supplies Biological Phenomena Persons
Subject	Dermatology Surgery

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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