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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Silva, José Alexandre da Costa Bomfim, Rangel Rodrigues Estevam, Charles dos Santos Antoniolli, Angelo Roberto Araújo, Adriano Antunes de Souza Thomazzi, Sara Maria |
Description | Country affiliation: Brazil Author Affiliation: Silva JA ( Pharmacology of Inflammation Laboratory, Federal University of Sergipe, 49100-000, São Cristóvão, Sergipe, Brazil.) |
Abstract | Cladonia clathrata Ahti & L. Xavier-Filho (Cladoniaceae) is a lichen; several Cladonia species extracts have been used for various remedies in folk medicine. In order to evaluate the actions of this lichen, studies were performed on antinociceptive, anti-inflammatory, and antioxidant activities. The hydroalcoholic extract (HE) of C. clathrata stems was used in the following experiments. Oral treatment with the HE of C. clathrata elicited inhibitory activity (p < 0.001) on acetic acid-induced abdominal writhes at 100 (47.2%), 200 (47.2%), and 400 mg/kg (86.4%), and reduced the formalin-induced nociception on both the neurogenic (400 mg/kg, p < 0.01) and inflammatory phases (200 and 400 mg/kg, p < 0.01). It was not associated with non-specific effects, such as muscle relaxation or sedation. The HE reduced the carrageenan-induced edema formation at 100, 200, and 400 mg/kg (p < 0.05) and inhibited neutrophil migration into the peritoneal cavity at 400 mg/kg (p < 0.001). The HE of C. clathrata reacted with the DPPH radical and reduced the same by 50.19%, and exhibited an IC(50) value of 69.25 +/- 0.65 mug/mL. The HE of C. clathrata stems shows antinociceptive and anti-inflammatory activities, with a moderate antioxidant potential. |
File Format | HTM / HTML |
ISSN | 13880209 |
e-ISSN | 17445116 |
Journal | Pharmaceutical Biology |
Issue Number | 7 |
Volume Number | 48 |
Language | English |
Publisher | Taylor & Francis |
Publisher Date | 2010-07-01 |
Publisher Place | Great Britain (UK) |
Access Restriction | Subscribed |
Subject Keyword | Discipline Pharmacology Analgesics Pharmacology Anti-inflammatory Agents Antioxidants Ascomycota Lichens Chemistry Animals Benzofurans Metabolism Biphenyl Compounds Carrageenan Drug Evaluation, Preclinical Mice Motor Activity Drug Effects Neutrophil Infiltration Pain Measurement Picrates Rats, Wistar Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject | Pharmaceutical Science Drug Discovery Pharmacology Molecular Medicine Complementary and Alternative Medicine |
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