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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Muratori, Luigi Muratori, Paolo Granito, Alessandro Pappas, Giorgios Cassani, Fabio Lenzi, Marco |
Description | Country affiliation: Italy Author Affiliation: Muratori L ( Department of Clinical Medicine, Alma Mater Studiorum - University of Bologna, Policlinico Sant'Orsola-Malpighi, Padiglione 11, Bologna, Italy. luigi.muratori@unibo.it) |
Abstract | Autoimmune hepatitis is a chronic liver disease of unknown aetiology characterized by interface hepatitis, hypergammaglobulinaemia and circulating autoantibodies. In the last decade a number of advancements have been made in the field of clinical and basic research: the simplified diagnostic criteria, the complete response defined as normalization of transaminase levels, the molecular identification of the antigenic targets of anti-liver cytosol antibody type 1 and anti-soluble liver antigen, the detection of anti-actin antibodies, the description of de novo autoimmune hepatitis after liver transplantation for non-autoimmune liver diseases, the characterization of autoimmune hepatitis with overlapping features of primary biliary cirrhosis or primary sclerosing cholangitis, the preliminary experience with novel treatment strategies based on cyclosporine, mycophenolate mofetil and budesonide, the role played by 'impaired' regulatory T cells and the development of novel animal models of autoimmune hepatitis. |
File Format | HTM / HTML |
ISSN | 15908658 |
Issue Number | 11 |
Volume Number | 42 |
e-ISSN | 18783562 |
Journal | Digestive and Liver Disease |
Language | English |
Publisher | Elsevier |
Publisher Date | 2010-11-01 |
Publisher Place | Netherlands |
Access Restriction | Subscribed |
Subject Keyword | Discipline Gastroenterology Hepatitis, Autoimmune Diagnosis Immunology Therapy Immunoglobulin G Animals Autoantibodies Autoantigens Biological Markers Blood Budesonide Therapeutic Use Cholangitis, Sclerosing Complications Cyclosporine Glucocorticoids Humans Hypergammaglobulinemia Immunity, Cellular Immunosuppressive Agents Liver Cirrhosis, Biliary Liver Transplantation Adverse Effects Mice Mycophenolic Acid Analogs & Derivatives Rats Transaminases Journal Article Review |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Eukaryota Digestive System Diseases Hemic and Lymphatic Diseases Organic Chemicals Polycyclic Compounds Hormones, Hormone Substitutes, and Hormone Antagonists Enzymes and Coenzymes Amino Acids, Peptides, and Proteins Biological Factors Chemical Actions and Uses Surgical Procedures, Operative Immune System Phenomena |
Subject | Hepatology Gastroenterology |
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