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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Dwyer, Julie M. Liu, Jun-Ping |
Description | Country affiliation: Australia Author Affiliation: Dwyer JM ( Department of Immunology, Molecular Signalling Laboratory, Monash University Central Clinical School, Melbourne, Victoria, Australia.) |
Abstract | 1. The enzyme telomerase maintains telomeres (ends of chromosomes) by synthesizing telomeric DNA at each end of the chromosomes. Its association with telomeres has implicated telomerase in cell immortalization. 2. Numerous studies have shown significant levels of telomerase activity in 85% of various types of cancer. Transcriptional control of the catalytic subunit, telomerase reverse transcriptase (TERT), dominates regulation of telomerase. Although several major factors have been identified in regulating TERT, they cannot explain all the transcriptional activity of the hTERT gene. 3. The Ets transcription factor (TF) family is becoming a regular feature in tumourigenesis, particularly in breast cancer. However, the roles and mechanisms of different Ets TFs are largely unknown. 4. The present minireview discusses the research that identified Ets as a regulator of telomerase required for breast cancer cell survival and proliferation, highlighting the discoveries central to understanding the molecular acts used by Ets TFs to mediate TERT gene transcription. |
File Format | HTM / HTML |
ISSN | 03051870 |
Issue Number | 1 |
Volume Number | 37 |
e-ISSN | 14401681 |
Journal | Clinical and Experimental Pharmacology and Physiology |
Language | English |
Publisher | Wiley-Blackwell |
Publisher Date | 2010-01-01 |
Publisher Place | Australia |
Access Restriction | Subscribed |
Subject Keyword | Discipline Physiology Discipline Pharmacology Breast Neoplasms Enzymology Genetics Gene Expression Regulation, Neoplastic Proto-oncogene Protein C-ets-2 Metabolism Telomerase Cell Survival Female Humans Proto-oncogene Protein C-ets-1 Proto-oncogene Proteins C-myc Stem Cells Telomere Journal Article Research Support, Non-u.s. Gov't Review |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Cells Eukaryota Neoplasms Enzymes and Coenzymes Amino Acids, Peptides, and Proteins Cell Physiological Phenomena Genetic Phenomena |
Subject | Physiology Pharmacology Physiology (medical) |
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