NDLI: Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schaeffer, Evelin L. da Silva, Emanuelle R. Novaes, Barbara de A. Skaf, Heni D. Gattaz, Wagner F.
Description	Country affiliation: Brazil Author Affiliation: Schaeffer EL ( Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Rua Dr. Ovídio Pires de Campos 785, 05403-010, Sao Paulo, SP, Brazil. schaffer@usp.br)
Abstract	The involvement of phospholipase A(2) (PLA(2)) in Alzheimer disease (AD) was first investigated nearly 15 years ago. Over the years, several PLA(2) isoforms have been detected in brain tissue: calcium-dependent secreted PLA(2) or sPLA(2) (IIA, IIC, IIE, V, X, and XII), calcium-dependent cytosolic PLA(2) or cPLA(2) (IVA, IVB, and IVC), and calcium-independent PLA(2) or iPLA(2) (VIA and VIB). Additionally, numerous in vivo and in vitro studies have suggested the role of different brain PLA(2) in both physiological and pathological events. This review aimed to summarize the findings in the literature relating the different brain PLA(2) isoforms with alterations found in AD, such as neuronal cell death and impaired neurogenesis process. The review showed that sPLA(2)-IIA, sPLA(2)-V and cPLA(2)-IVA are involved in neuronal death, whereas sPLA(2)-III and sPLA(2)-X are related to the process of neurogenesis, and that the cPLA(2) and iPLA(2) groups can be involved in both neuronal death and neurogenesis. In AD, there are reports of reduced activity of the cPLA(2) and iPLA(2) groups and increased expression of sPLA(2)-IIA and cPLA(2)-IVA. The findings suggest that the inhibition of cPLA(2) and iPLA(2) isoforms (yet to be determined) might contribute to impaired neurogenesis, whereas stimulation of sPLA(2)-IIA and cPLA(2)-IVA might contribute to neurodegeneration in AD.
File Format	HTM / HTML
ISSN	02785846
Issue Number	8
Volume Number	34
e-ISSN	18784216
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Psychiatry Alzheimer Disease Enzymology Pathology Neurogenesis Physiology Neurons Phospholipases A2 Animals Cell Death Humans Cytology Phospholipase A2 Inhibitors Comparative Study Journal Article Review
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Nervous System Eukaryota Nervous System Diseases Enzymes and Coenzymes Chemical Actions and Uses Cell Physiological Phenomena
Subject	Pharmacology Biological Psychiatry

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