NDLI: Excess mortality and cause of death in a cohort of Norwegian multiple sclerosis patients.

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Excess mortality and cause of death in a cohort of Norwegian multiple sclerosis patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smestad, C. Sandvik, L. Celius, E. G.
Spatial Coverage	Norway
Description	Country affiliation: Norway Author Affiliation: Smestad C ( Department of Neurology, Oslo University Hospital, Oslo, Norway. smec@uus.no)
Abstract	There are few studies of long-term, cause-specific mortality in multiple sclerosis (MS) relating to population mortality. Our objective was to study survival, excess mortality and causes of death in a cohort of patients with a long history of MS. Patients living in Oslo with definite MS and onset during 1940-80 were included in 2006. Causes of death and mortality in the general population were obtained from the Cause of Death Registry of Statistics Norway. Of the 386 patients included in the study, 263 (68%) had died at inclusion. Median survival from onset was 35 years (Kaplan-Meier: 95% confidence interval 33-37). Primary progressive MS was associated with shorter survival, but mean age at death was similar for relapsing-remitting and primary progressive MS patients. The most frequent underlying cause of death was MS (50%), and infection was often registered as a contributory cause (56%). The all-cause standardized mortality ratio was 2.47. Excess mortality was most marked during the second decade after onset of MS. We conclude that infections are probably the main cause of death in patients with MS, but the frequency is underestimated due to misleading information on death certificates. Excess mortality in patients with MS first appeared during the second decade of the disease. Survival seems to be age-dependent rather than related to disease course.
File Format	HTM / HTML
ISSN	13524585
Issue Number	11
Volume Number	15
e-ISSN	14770970
Journal	Multiple Sclerosis Journal
Language	English
Publisher	SAGE Publications
Publisher Date	2009-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Neurology Multiple Sclerosis Mortality Adolescent Adult Age Of Onset Aged Cause Of Death Cohort Studies Disease Progression Female Forecasting Humans Kaplan-meier Estimate Male Middle Aged Complications Norway Epidemiology Risk Assessment Survival Analysis Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Eukaryota Nervous System Diseases Pathological Conditions, Signs and Symptoms Investigative Techniques Social Sciences Persons Health Care Quality, Access, and Evaluation Geographic Locations
Subject	Neurology Neurology (clinical)

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