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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Locci, M. Nazzaro, G. Miranda, M. Salzano, E. Montagnani, S. Castaldo, C. De Placido, G. |
Description | Country affiliation: Italy Author Affiliation: Locci M ( Department of Obstetrics and Gynecology, Naples, Italy. mariavittorialocci@virgilio.it) |
Abstract | A total of 3,324 singleton pregnant women were screened for pre-term delivery and 128 women were finally randomised and analysed for outcome showing borderline cervical length (25-29 mm) and elevated cervico-vaginal interleukin 6 levels. To verify if vaginal administration of lactoferrin might have an influence on these variables, two groups of 64 patients were formed. Study cases were submitted to lactoferrin for 21 days; controls received no treatment. An inverse relation was found between interleukin 6 levels and cervical length. On day 30 from the beginning of the treatment, study cases showed a decrease in interleukin 6 levels and an increase in cervical length. A greater number of women with regular uterine contractions and reduced cervical consistency before the 37th week of gestation were found in the controls. Our data show that lactoferrin could play a role in reducing the number of women at risk for pre-term birth for shortened cervical length and elevated interleukin 6 levels. |
File Format | HTM / HTML |
ISSN | 01443615 |
Issue Number | 2 |
Volume Number | 33 |
e-ISSN | 13646893 |
Journal | Journal of Obstetrics and Gynaecology |
Language | English |
Publisher | Taylor & Francis |
Publisher Date | 2013-02-01 |
Publisher Place | Great Britain (UK) |
Access Restriction | Subscribed |
Subject Keyword | Prospective Studies Biological Markers Discipline Obstetrics Administration, Intravaginal Journal Article Interleukin-6 Lactoferrin Cattle Female Anti-infective Agents Clinical Trial Prevention & Control Vaginal Smears Pharmacology Cervix Uteri Metabolism Obstetric Labor, Premature Randomized Controlled Trial Cervical Length Measurement Drug Effects Therapeutic Use Pregnancy Animals Discipline Gynaecology Longitudinal Studies |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Urogenital System Eukaryota Female Urogenital Diseases and Pregnancy Complications Enzymes and Coenzymes Amino Acids, Peptides, and Proteins Chemical Actions and Uses Diagnosis Therapeutics Investigative Techniques Reproductive and Urinary Physiological Phenomena |
Subject | Obstetrics and Gynecology |
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