NDLI: Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice.

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Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ford, Nikki A. Clinton, Steven K. Von Lintig, Johannes Wyss, Adrian Erdman, John W.
Description	Country affiliation: United States Author Affiliation: Ford NA ( Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.)
Abstract	Two enzymes have been identified for the oxidative metabolism of carotenoids in mammals. Carotene-15,15'-monooxygenase (CMO-I) primarily centrally cleaves ß,ß-carotene to form vitamin A. We hypothesize that carotene-9',10'-monooxygenase (CMO-II) plays a key role in metabolism of acyclic nonprovitamin A carotenoids such as lycopene. We investigated carotenoid bioaccumulation in young adult, male, wild-type (WT) mice or mice lacking CMO-II (CMO-II KO). Mice were fed an AIN-93G diet or identical diets supplemented with 10% tomato powder, 130 mg lycopene/kg diet (10% lycopene beadlets), or placebo beadlets for 4 or 30 d. Lycopene preferentially accumulated in CMO-II KO mouse tissues and serum compared with WT mouse tissues. ß-Carotene preferentially accumulated in some CMO-II KO mouse tissues compared with WT mouse tissues. Relative tissue mRNA expression of CMO-I and CMO-II was differentially expressed in mouse tissues, and CMO-II, but not CMO-I, was expressed in mouse prostate. In conclusion, the loss of CMO-II expression leads to increased serum and tissue concentrations of lycopene in tomato-fed mice.
File Format	HTM / HTML
ISSN	00223166
e-ISSN	15416100
DOI	10.3945/jn.110.128033
Journal	Journal of Nutrition
Issue Number	12
Volume Number	140
Language	English
Publisher	American Society for Nutrition
Publisher Date	2010-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dna Primers Research Support, N.i.h., Extramural Body Weight Mice, Inbred C57bl Rna, Messenger Organ Size Administration & Dosage Chromatography, High Pressure Liquid Metabolism Blood Carotenoids Animals Fatty Acid Desaturases Polymerase Chain Reaction Placebos Genetics Mice Discipline Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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Loss of Carotene-9′,10’-Monooxygenase Expression Increases Serum and Tissue Lycopene Concentrations in Lycopene-Fed Mice 1 2 3

Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice.

Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice.

High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats.

Independent positive association of plasma β-carotene concentrations with adiponectin among non-diabetic obese subjects

Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans

Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats.

High Preformed Vitamin A Intake during Pregnancy Prevents Embryonic Accumulation of Intact ß-Carotene from the Maternal Circulation in Mice.

Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice

Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice.

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Loss of Carotene-9′,10’-Monooxygenase Expression Increases Serum and Tissue Lycopene Concentrations in Lycopene-Fed Mice 1 2 3

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Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice.