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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Isir, Aysun Baransel Dai, Alper Ibrahim Nacak, Muradiye Gorucu, Senay |
Spatial Coverage | Turkey |
Description | Country affiliation: Turkey Author Affiliation: Isir AB ( Department of Forensic Medicine, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. aybaransel@yahoo.com) |
Abstract | Little is known about criminality of cognitively impaired people and also there have been no reports on the relationship between catechol-O-methyl transferase (COMT) and committed Mental Retardation (MR) subjects. In the present study, the association between committed (violent offences) MR subjects and genetic variants of COMT were investigated by using polymerase chain reaction and based restriction fragment length polymorphism methods. During 6 years of follow-up, 36 violent offenders with mild MR were investigated. Thirty-six control volunteers were included in the study as a control group. H/L polymorphism of the COMT gene was investigated in these two groups. In conclusion, the COMT gene genotype distribution and allele frequency is not significantly different between the two groups (p > 0.05). This result suggests that the H/L polymorphism of the COMT gene does not show an association with the potential of 'commits-violent offense' of Turkish subjects with mental retardation, compared with control group. |
File Format | HTM / HTML |
ISSN | 00221198 |
Issue Number | 1 |
Volume Number | 55 |
e-ISSN | 15564029 |
Journal | Journal of Forensic Sciences |
Language | English |
Publisher | Wiley-Blackwell |
Publisher Date | 2010-01-01 |
Publisher Place | United States |
Access Restriction | Subscribed |
Subject Keyword | Violence Gene Frequency Humans Genotype Male Discipline Forensic Sciences Catechol O-methyltransferase Epidemiology Journal Article Case-control Studies Turkey Polymorphism, Restriction Fragment Length Follow-up Studies Adolescent Polymerase Chain Reaction Genetics Female Intellectual Disability |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Eukaryota Nervous System Diseases Enzymes and Coenzymes Investigative Techniques Genetic Phenomena Social Sciences Persons Geographic Locations |
Subject | Pathology and Forensic Medicine Genetics |
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