NDLI: Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pandit, Rahul Luijendijk, Mieneke C. M. Vanderschuren, Louk J. M. J. La Fleur, Susanne E. Adan, Roger A. H.
Description	Country affiliation: Netherlands Author Affiliation: Pandit R ( Department of Translational Neuroscience Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.)
Abstract	OBJECTIVE: Neuropeptide Y (NPY), given centrally augments food intake and the motivation to work for palatable food. Here, the brain regions were identified through which NPY increases food intake and motivation. METHODS: NPY was infused into three brain regions implicated in food intake and motivation: the lateral hypothalamus (LH), nucleus accumbens shell (NAc), and ventral tegmental area (VTA). Motivation for sucrose was assessed using a progressive-ratio schedule of reinforcement in which the effort to obtain successive rewards increased incrementally. To disentangle the effects of NPY on motivation for palatable food from food consumption, free-feeding experiments were performed in which animals had ad libitum access to sucrose pellets. RESULTS: Infusion of NPY into either VTA or NAc increased the motivation to respond for sucrose, whereas infusion of NPY in either NAc or LH increased sucrose consumption. In addition, the effect of intra-VTA NPY on motivation for food was attenuated after pretreatment with the dopamine receptor antagonist alpha-flupenthixol. CONCLUSIONS: Specific limbic substrates through which NPY influences consumption of and motivation for palatable food were identified by these data. The motivational effects of NPY are exerted through the VTA, its consummatory effects through the LH, and the NAc is involved in both.
File Format	HTM / HTML
ISSN	19307381
Issue Number	5
Volume Number	22
e-ISSN	1930739X
Journal	Obesity
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-05-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Endocrinology Feeding Behavior Drug Effects Motivation Neuropeptide Y Pharmacology Animals Hypothalamic Area, Lateral Metabolism Male Nucleus Accumbens Rats Rats, Wistar Sucrose Administration & Dosage Ventral Tegmental Area Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Nervous System Eukaryota Carbohydrates Amino Acids, Peptides, and Proteins Behavior and Behavior Mechanisms
Subject	Nutrition and Dietetics Endocrinology Endocrinology, Diabetes and Metabolism

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Libarray of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats.

Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake.

Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226.

Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions.

Effects of naltrexone on nucleus accumbens, lateral hypothalamic and ventral tegmental self-stimulation rate—frequency functions

Nicotinic acetylcholine receptors in the anterior, but not posterior, ventral tegmental area mediate ethanol-induced elevation of accumbal dopamine levels.

Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation

Involvement of orexin-1 receptors in the ventral tegmental area and the nucleus accumbens in antinociception induced by lateral hypothalamus stimulation in rats.

Afferent neuropeptide Y projections to the ventral tegmental area in normal‐weight male Wistar rats

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.

Similar Documents

Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats.

Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake.

Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226.

Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions.

Effects of naltrexone on nucleus accumbens, lateral hypothalamic and ventral tegmental self-stimulation rate—frequency functions

Nicotinic acetylcholine receptors in the anterior, but not posterior, ventral tegmental area mediate ethanol-induced elevation of accumbal dopamine levels.

Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation

Involvement of orexin-1 receptors in the ventral tegmental area and the nucleus accumbens in antinociception induced by lateral hypothalamus stimulation in rats.

Afferent neuropeptide Y projections to the ventral tegmental area in normal‐weight male Wistar rats

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.