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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Yeung, Sonia N. Ku, Judy Y. F. Lichtinger, Alejandro Low, Stephanie A. W. Kim, Peter Rootman, David S. |
Description | Country affiliation: Canada Author Affiliation: Yeung SN ( Yonge Eglinton Laser Eye Centre and the Department of Ophthalmology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. sonia.y@gmail.com) |
Abstract | PURPOSE: To evaluate the efficacy of single or paired intrastromal corneal ring segments (ICRS) combined with ultraviolet-A and riboflavin collagen crosslinking (CXL) in patients with keratoconus. SETTING: Cornea Unit, Toronto Western Hospital, Toronto, Ontario, Canada. DESIGN: Retrospective comparative case series. METHODS: Consecutive patients with keratoconus had femtosecond laser-assisted ICRS implantation combined with same-day CXL between 2008 and 2011. The main outcome measures included improvement in visual acuity, subjective refractive error, keratometry values, and total higher-order aberration (HOA). RESULTS: Eighty-five eyes of 74 patients with keratoconus (paired ICRS: 47 eyes of 40 patients; single ICRS: 38 eyes of 34 patients) were included in the study. The uncorrected distance visual acuity was significantly improved after single ICRS (3.4 lines; P=.04) and paired ICRS (2.7 lines; P=.01) implantation combined with CXL, while corrected distance visual acuity (CDVA) remained stable. The single and paired ICRS groups had a significant reduction in mean cylinder at 1 year (single ICRS: -3.84 diopters [D] ± 1.72 [SD] versus -2.19 ± 1.54 D, P=.02; paired ICRS: -3.91 ± 1.45 D versus -2.96 ± 1.92 D) (P=.02). There was no significant difference in total HOAs. Single ICRS implantation and paired ICRS implantation with CXL were equivalent in all refractive parameters. No patient lost lines of CDVA. CONCLUSION: As determined by corneal topography, implantation of single or paired ICRS combined with same-day CXL was safe and effective in patients with keratoconus. |
File Format | HTM / HTML |
ISSN | 08863350 |
Issue Number | 8 |
Volume Number | 39 |
e-ISSN | 18734502 |
Journal | Journal of Cataract & Refractive Surgery |
Language | English |
Publisher | Elsevier |
Publisher Date | 2013-08-01 |
Publisher Place | United States |
Access Restriction | Subscribed |
Subject Keyword | Discipline Ophthalmology Collagen Metabolism Corneal Stroma Surgery Cross-linking Reagents Therapeutic Use Keratoconus Therapy Photochemotherapy Prostheses And Implants Prosthesis Implantation Adult Combined Modality Therapy Corneal Topography Female Humans Drug Therapy Male Photosensitizing Agents Prognosis Retrospective Studies Riboflavin Ultraviolet Rays Visual Acuity Physiology Comparative Study Journal Article |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Sense Organs Eukaryota Eye Diseases Heterocyclic Compounds Macromolecular Substances Chemical Actions and Uses Diagnosis Therapeutics Surgical Procedures, Operative Investigative Techniques Equipment and Supplies Physical Phenomena Persons |
Subject | Sensory Systems Ophthalmology Surgery |
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